Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | ACE | P12821 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NT5C2 | P49902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9173805 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL9853721 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPK1HSD17B10LMNANT5C2 | |
| SCHEMBL15730821 | 0.75 | KDM4E (0.42) | SMN1; SMN2EGLN1MAPTMAPK1HSD17B10 | |
| Glutathione SCHEMBL11157996 | 0.74 | PTGS1 (0.66) | PTGS1GSTK1EGLN1 | |
| SCHEMBL9177444 | 0.70 | NOTUM (0.40) | SMN1; SMN2EGLN1ALDH1A1HPGDMEN1 | |
| SCHEMBL19576335 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19576298 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19576317 | 0.69 | SMN1; SMN2 (0.49) | SMN1; SMN2HPGDHSD17B10KMT2A | |
| SCHEMBL17234487 | 0.67 | L3MBTL1 (0.45) | EGLN1ALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL30919984 | 0.67 | L3MBTL1 (0.45) | EGLN1ALDH1A1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426467-A1 | Prodrugs of 6-mercaptopurine and 6-thioguanine | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1991-05-08 | — | — | EP | disclosed |