Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9854699 | 0.74 | MTNR1A (0.52) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| SCHEMBL8334238 | 0.72 | SMN1; SMN2 (0.68) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| SCHEMBL25695438 | 0.72 | SMN1; SMN2 (0.68) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| SCHEMBL3070121 | 0.72 | MTNR1A (1.00) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| SCHEMBL54783 | 0.72 | MTNR1A (1.00) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| SCHEMBL3070126 | 0.72 | MTNR1A (1.00) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| SCHEMBL29759505 | 0.72 | MTNR1A (1.00) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL28626845 | 0.71 | SMN1; SMN2 (0.66) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| SCHEMBL9731350 | 0.71 | MTNR1A (0.66) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| SCHEMBL21285350 | 0.68 | TRPV1 (0.38) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420064-A2 | Substituted 2-amidotetralins as melatonin agonists and antagonists | NORTHWESTERN UNIVERSITY (US) | 1991-04-03 | — | — | EP | disclosed |