Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9854743 | 0.90 | MTNR1A (0.54) | MTNR1AMTNR1BMEN1KMT2AALDH1A1 | |
| SCHEMBL9854709 | 0.85 | MTNR1A (0.49) | MTNR1AMTNR1BMAPTMEN1KMT2A | |
| SCHEMBL11252364 | 0.79 | ATM (0.55) | MTNR1AMTNR1BCYP1A2ALOX15MAPT | |
| SCHEMBL17335683 | 0.77 | ALDH1A1 (0.61) | MTNR1AMTNR1BMEN1KMT2ATSHR | |
| SCHEMBL26779718 | 0.77 | ALDH1A1 (0.61) | MTNR1AMTNR1BMEN1KMT2ATSHR | |
| SCHEMBL7445856 | 0.77 | ALDH1A1 (0.61) | MTNR1AMTNR1BMEN1KMT2ATSHR | |
| SCHEMBL9854669 | 0.77 | TRPV1 (0.53) | MTNR1AMTNR1BCYP1A2ALOX15MEN1 | |
| SCHEMBL9854681 | 0.74 | MTNR1A (0.56) | MTNR1AMTNR1BCYP1A2ALOX15MEN1 | |
| SCHEMBL8402847 | 0.74 | MTNR1A (0.55) | MTNR1AMTNR1BCYP1A2ALOX15MAPT | |
| SCHEMBL659023 | 0.72 | ALDH1A1 (0.74) | MEN1KMT2ATSHRALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420064-A2 | Substituted 2-amidotetralins as melatonin agonists and antagonists | NORTHWESTERN UNIVERSITY (US) | 1991-04-03 | — | — | EP | disclosed |