Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9855381 | 0.86 | CYP26A1 (0.60) | CYP19A1ALDH1A1TP53CYP1A2CYP3A4 | |
| SCHEMBL9938106 | 0.85 | HTR2C (0.47) | CYP19A1METAP1 | |
| SCHEMBL9048859 | 0.82 | CYP19A1 (0.58) | CYP19A1MEN1GLAKMT2AGAA | |
| SCHEMBL31374607 | 0.81 | METAP1 (0.55) | CYP19A1METAP1 | |
| SCHEMBL13048335 | 0.81 | MIF (0.46) | MEN1GLAKMT2AGAAKDM4E | |
| SCHEMBL13048317 | 0.81 | MIF (0.46) | MEN1GLAKMT2AGAAKDM4E | |
| SCHEMBL9938389 | 0.81 | METAP1 (0.55) | CYP19A1METAP1 | |
| SCHEMBL17144641 | 0.80 | METAP1 (0.45) | KMT2AGAAMETAP1MIF | |
| SCHEMBL14026621 | 0.79 | ACHE (0.55) | KMT2AGAA | |
| SCHEMBL3413462 | 0.78 | MIF (0.46) | MEN1GLAKMT2AGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4983628-A | ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY AND CYTOPROTECTIVE AGENTS | MERCK FROSST CANADA, INC. (CA) | 1991-01-08 | — | — | US | disclosed |
| EP-0140684-B1 | LEUKOTRIENE ANTAGONISTS | MERCK FROSST CANADA INC. (CA) | 1990-07-11 | — | — | EP | disclosed |
| US-4683325-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | MERCK FROSST CANADA, INC. (CA) | 1987-07-28 | — | — | US | disclosed |
| EP-0140684-A2 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1985-05-08 | — | — | EP | disclosed |