Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10639380 | 0.94 | KDM4E (0.49) | ALDH1A1MAPTHPGDKDM4ECYP2D6 | |
| SCHEMBL24064971 | 0.90 | SMN1; SMN2 (0.48) | ALDH1A1MAPTKDM4ENPC1KMT2A | |
| SCHEMBL5723831 | 0.87 | ALDH1A1 (0.45) | ALDH1A1MAPTHPGDKDM4ENPC1 | |
| SCHEMBL5723815 | 0.87 | ALDH1A1 (0.45) | ALDH1A1MAPTHPGDKDM4ENPC1 | |
| SCHEMBL3789109 | 0.87 | SMN1; SMN2 (0.51) | MAPTCYP2D6GRIN2BNPC1LMNA | |
| SCHEMBL3615713 | 0.87 | SMN1; SMN2 (0.51) | MAPTCYP2D6GRIN2BNPC1LMNA | |
| SCHEMBL8788495 | 0.87 | SMN1; SMN2 (0.51) | MAPTCYP2D6GRIN2BNPC1LMNA | |
| SCHEMBL10639596 | 0.83 | GRIN2B (0.56) | ALDH1A1MAPTHPGDKDM4EGRIN2B | |
| SCHEMBL6767786 | 0.82 | KDM4E (0.43) | ALDH1A1MAPTKDM4ENPC1LMNA | |
| SCHEMBL5724304 | 0.81 | ALDH1A1 (0.47) | ALDH1A1MAPTHPGDKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071843-A | Thienamycin antibiotics with delayed metabolism | MERCK & CO., INC. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0161541-B1 | 6-[1-Hydroxyethyl]-2-SR8-1-methyl-1-carba-dethiapen-2-em-3-carboxylic acids | MERCK & CO. INC. (US) | 1990-12-12 | — | — | EP | disclosed |
| EP-0161546-B1 | COMBINATION OF 2-SUBSTITUTED CARBAPENEMS WITH DIPEPTIDASE INHIBITORS | MERCK & CO. INC. (US) | 1989-12-13 | — | — | EP | disclosed |
| US-4696923-A | THIENAMYCIN ANTIBIOTICS, BACTERICIDES | MERCK & CO., INC. (US) | 1987-09-29 | — | — | US | disclosed |
| EP-0161546-A1 | Combination of 2-substituted carbapenems with dipeptidase inhibitors | MERCK & CO. INC. (US) | 1985-11-21 | — | — | EP | disclosed |
| EP-0161541-A1 | 6-[1-Hydroxyethyl]-2-SR8-1-methyl-1-carba-dethiapen-2-em-3-carboxylic acids | MERCK & CO. INC. (US) | 1985-11-21 | — | — | EP | disclosed |