Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | GSK3B | P49841 | 2/20 | 0.67 |
| ▸ | F3 | P13726 | 2/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9855983 | 1.00 | LMNA (0.68) | LMNATDP1GSK3BF3THRB | |
| SCHEMBL8444968 | 0.89 | LMNA (0.60) | LMNATDP1GSK3BF3THRB | |
| 4-Methoxy Ethyl Cinnamate SCHEMBL15190 | 0.88 | CA12 (0.71) | LMNATDP1GSK3BF3THRB | |
| 4-Methoxy Ethyl Cinnamate SCHEMBL1056347 | 0.88 | CA12 (0.71) | LMNATDP1GSK3BF3THRB | |
| 4-Methoxy Ethyl Cinnamate SCHEMBL434842 | 0.88 | CA12 (0.71) | LMNATDP1GSK3BF3THRB | |
| SCHEMBL2135887 | 0.87 | KMT2A (0.66) | LMNATDP1GSK3BF3THRB | |
| SCHEMBL10428067 | 0.87 | LMNA (0.69) | LMNATDP1GSK3BF3THRB | |
| SCHEMBL2135879 | 0.87 | KMT2A (0.66) | LMNATDP1GSK3BF3THRB | |
| SCHEMBL10428068 | 0.87 | LMNA (0.65) | LMNATDP1GSK3BF3THRB | |
| SCHEMBL10428069 | 0.87 | LMNA (0.65) | LMNATDP1GSK3BF3THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263492-B1 | RETINOIDS, THEIR PREPARATION AND USE AS PHARMACEUTICAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-03-13 | — | — | EP | claimed |
| US-4900478-A | SKIN DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-02-13 | — | — | US | claimed |
| US-4900478-A | SKIN DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-02-13 | — | — | US | disclosed |