Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | MDM4 | O15151 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 4/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL981903 | 0.91 | HTR4 (0.38) | BTKCRHR1CRHR2PTK2 | |
| SCHEMBL984217 | 0.91 | HTR4 (0.38) | BTKCRHR1CRHR2PTK2 | |
| SCHEMBL984745 | 0.90 | BTK (0.39) | BTKKDM2BKDM4CADORA2AADORA1 | |
| SCHEMBL984520 | 0.90 | MDM4 (0.37) | BTKKDM2BKDM4CADORA2AADORA1 | |
| SCHEMBL983256 | 0.89 | BTK (0.42) | BTKADORA2AADORA1MDM4TAS1R3 | |
| SCHEMBL984905 | 0.89 | KDM1A (0.42) | BTKKDM2BKDM4CADORA2AADORA1 | |
| SCHEMBL984583 | 0.88 | LMNA (0.38) | BTKKDM2BKDM4CADORA2AADORA1 | |
| SCHEMBL981511 | 0.88 | KDM1A (0.42) | KDM2BKDM4CADORA2AADORA1MDM4 | |
| SCHEMBL986033 | 0.88 | CSNK2A2 (0.38) | BTKKDM2BKDM4CADORA2AADORA1 | |
| SCHEMBL986034 | 0.88 | CSNK2A2 (0.38) | BTKKDM2BKDM4CADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | claimed |
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | BTK 1977/4885KDM2B 831/4885KDM4C 599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.