Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isophthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | UNG | P13051 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isophthalic Acid SCHEMBL1801282 | 1.00 | CA12 (0.50) | CA12CA1CA2CA6CA9 | |
| Isophthalic Acid SCHEMBL28960768 | 0.96 | CA12 (0.47) | CA12CA1CA2CA6CA9 | |
| Isophthalic Acid SCHEMBL11132241 | 0.91 | UNG (0.43) | CA12CA1CA2CA6CA9 | |
| Propylene Glycol SCHEMBL31734112 | 0.91 | ATM (0.60) | CA1CA2CA9HSD17B10HPGD | |
| Isophthalic Acid SCHEMBL11132245 | 0.91 | UNG (0.43) | CA12CA1CA2CA6CA9 | |
| Isophthalic Acid SCHEMBL31359378 | 0.90 | HDAC3 (0.46) | CA12CA1CA2CA6CA9 | |
| Propylene Glycol SCHEMBL28663698 | 0.88 | CYP4F2 (0.53) | FOLH1HSD17B10HPGDMEP1BTSHR | |
| Isophthalic Acid SCHEMBL9133851 | 0.88 | CA12 (0.50) | CA12CA1CA2CA6CA9 | |
| Propylene Glycol SCHEMBL5079139 | 0.88 | NPC1 (0.50) | HPGDKMT2A | |
| Benzoic Acid SCHEMBL524377 | 0.88 | TSHR (0.61) | TP53HPGDKMT2ADAOTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990397-A | High impact strength | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1991-02-05 | — | — | US | disclosed |
| US-4943474-A | CIRCUIT BOARDS, MIXTURE OF HARD AND SOFT POLYMERS | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-07-24 | — | — | US | disclosed |
| EP-0377769-A1 | Unsaturated polyester resin compositions and electrical laminates made therefrom | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-07-18 | — | — | EP | disclosed |
| US-RE31961-E | High solids pigment coating composition | AKZO NV (NL) | 1985-07-30 | — | — | US | disclosed |
| EP-0018052-B1 | PIGMENT-CONTAINING COATING COMPOSITION HAVING A HIGH SOLIDS CONTENT | AKZO N.V. (NL) | 1983-06-01 | — | — | EP | disclosed |
| EP-0018051-B1 | PIGMENT-CONTAINING COATING COMPOSITION HAVING A HIGH SOLIDS CONTENT | AKZO N.V. (NL) | 1983-05-11 | — | — | EP | disclosed |
| US-4279800-A | High solids pigmented coating composition containing a blend of ester diols and a curing agent | AKZO NV (NL) | 1981-07-21 | — | — | US | disclosed |
| US-4271062-A | ESTER DIOL BLEND WITH CURING AGENT, PRIMERS, TOP COATS | AKZO N.V. (NL) | 1981-06-02 | — | — | US | disclosed |
| EP-0018051-A1 | Pigment-containing coating composition having a high solids content | AKZO N.V. (NL) | 1980-10-29 | — | — | EP | disclosed |
| EP-0018052-A1 | Pigment-containing coating composition having a high solids content | AKZO N.V. (NL) | 1980-10-29 | — | — | EP | disclosed |
| US-4104240-A | ESTER DIOLS, AMINOPLAST CURING AGENT | AKZO N.V. (NL) | 1978-08-01 | — | — | US | disclosed |