Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 3/20 | 0.45 |
| ▸ | APAF1 | O14727 | 2/20 | 0.40 |
| ▸ | TDP2 | O95551 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL917366 | 0.83 | CDC25B (0.56) | CDC25BAPAF1TDP2MAPTTP53 | |
| SCHEMBL1151720 | 0.83 | CDC25B (0.56) | CDC25BAPAF1TDP2MAPTTP53 | |
| SCHEMBL1542903 | 0.83 | CDC25B (0.56) | CDC25BAPAF1TDP2MAPTTP53 | |
| SCHEMBL8149979 | 0.82 | APAF1 (0.43) | CDC25BAPAF1TDP2MAPTTP53 | |
| SCHEMBL9857346 | 0.79 | APAF1 (0.54) | CDC25BAPAF1TDP2MAPTTP53 | |
| Parvaquone SCHEMBL916441 | 0.78 | APAF1 (0.52) | CDC25BAPAF1TDP2MAPTTP53 | |
| SCHEMBL11116588 | 0.78 | APAF1 (0.52) | CDC25BAPAF1TDP2MAPTTP53 | |
| SCHEMBL11121475 | 0.78 | APAF1 (0.52) | CDC25BAPAF1TDP2MAPTTP53 | |
| Parvaquone SCHEMBL31326459 | 0.78 | APAF1 (0.52) | CDC25BAPAF1TDP2MAPTTP53 | |
| SCHEMBL11120067 | 0.78 | APAF1 (0.52) | CDC25BAPAF1TDP2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5053418-A | Synergistic mixture of 2-(4,-(4-chlorophenyl)cyclohexyl)3-hydr oxy-1,4 napthoquinone and 3,5-dichloro-2,6 dichloropyridinol | BURROUGHS WELLCOME CO. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0123239-B1 | IMPROVEMENTS IN OR RELATING TO ANTIPROTOZOAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-09-11 | — | — | EP | disclosed |
| EP-0401875-A2 | Improvements in or relating to antiprotozoal agents | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-12-12 | — | — | EP | disclosed |
| EP-0123239-A2 | Improvements in or relating to antiprotozoal agents | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-10-31 | — | — | EP | disclosed |