Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 2/20 | 0.54 |
| ▸ | TDP2 | O95551 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | PTPRC | P08575 | 2/20 | 0.49 |
| ▸ | CDC25B | P30305 | 2/20 | 0.49 |
| ▸ | PTPRF | P10586 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Parvaquone SCHEMBL916441 | 0.98 | APAF1 (0.52) | APAF1TDP2MAPTMEN1KMT2A | |
| SCHEMBL11120067 | 0.98 | APAF1 (0.52) | APAF1TDP2MAPTMEN1KMT2A | |
| Parvaquone SCHEMBL31326459 | 0.98 | APAF1 (0.52) | APAF1TDP2MAPTMEN1KMT2A | |
| SCHEMBL11121475 | 0.98 | APAF1 (0.52) | APAF1TDP2MAPTMEN1KMT2A | |
| SCHEMBL11116588 | 0.98 | APAF1 (0.52) | APAF1TDP2MAPTMEN1KMT2A | |
| SCHEMBL16363681 | 0.91 | MAPT (0.57) | APAF1TDP2MAPTMEN1KMT2A | |
| SCHEMBL9579933 | 0.89 | MAPT (0.49) | APAF1TDP2MAPTMEN1KMT2A | |
| SCHEMBL29360603 | 0.86 | MAPT (0.64) | APAF1TDP2MAPTMEN1KMT2A | |
| SCHEMBL16621117 | 0.86 | MAPT (0.64) | APAF1TDP2MAPTMEN1KMT2A | |
| SCHEMBL8136452 | 0.84 | MAPT (0.51) | APAF1TDP2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002228-A2 | Hydroxy naphthoquinone derivatives, their preparations for treating and preventing theileriosis in cattle and sheep, processes for their synthesis; naphthoquinone derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-06-13 | — | — | EP | claimed |
| US-5053418-A | Synergistic mixture of 2-(4,-(4-chlorophenyl)cyclohexyl)3-hydr oxy-1,4 napthoquinone and 3,5-dichloro-2,6 dichloropyridinol | BURROUGHS WELLCOME CO. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0123239-B1 | IMPROVEMENTS IN OR RELATING TO ANTIPROTOZOAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-09-11 | — | — | EP | disclosed |
| EP-0401875-A2 | Improvements in or relating to antiprotozoal agents | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-12-12 | — | — | EP | disclosed |
| EP-0123239-A2 | Improvements in or relating to antiprotozoal agents | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-10-31 | — | — | EP | disclosed |