Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | UTS2R | Q9UKP6 | 8/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 4/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9856945 | 0.86 | HTR2A (0.49) | SLC6A9SLC6A4HTR2ASIGMAR1 | |
| SCHEMBL9857350 | 0.84 | SLC6A9 (0.67) | SLC6A9SLC6A4HRH3UTS2RHTR2A | |
| SCHEMBL9856509 | 0.81 | HTR2A (0.51) | SLC6A9SLC6A4HRH3HTR2AHTR2B | |
| SCHEMBL9857184 | 0.81 | UTS2R (0.46) | SLC6A9SLC6A4HRH3UTS2RHTR2A | |
| SCHEMBL9857027 | 0.78 | HTR2A (0.49) | SLC6A9SLC6A4HTR2AHTR2BHTR2C | |
| SCHEMBL9857304 | 0.74 | TAAR1 (0.50) | SLC6A9SLC6A4HTR2ALMNAMAPT | |
| SCHEMBL13204407 | 0.73 | SLC6A9 (0.63) | SLC6A9SLC6A4HRH3HTR2AHTR2B | |
| SCHEMBL10594964 | 0.73 | TAAR1 (0.33) | HTR2ALMNAMAPT | |
| SCHEMBL9857092 | 0.73 | TAAR1 (0.36) | SLC6A4HRH3HTR2A | |
| SCHEMBL9857061 | 0.70 | SLC6A4 (0.42) | SLC6A9SLC6A4HRH3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0318233-A2 | Improvements in or relating to serotonin and norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |