Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9856994 | 0.77 | MEN1 (0.48) | SLC6A9SLC6A4HRH3HTR2AHRH1 | |
| SCHEMBL9857074 | 0.76 | CYSLTR2 (0.47) | SLC6A4HRH3HTR2AHRH1CHRM1 | |
| SCHEMBL9857350 | 0.76 | SLC6A9 (0.67) | SLC6A9SLC6A4HRH3HTR2AHRH1 | |
| SCHEMBL9856509 | 0.75 | HTR2A (0.51) | SLC6A9SLC6A4HRH3HTR2AHRH1 | |
| SCHEMBL9856705 | 0.73 | HTR2A (0.47) | SLC6A9SLC6A4HRH3HTR2AHRH1 | |
| SCHEMBL9857027 | 0.72 | HTR2A (0.49) | SLC6A9SLC6A4HTR2AHRH1CHRM2 | |
| SCHEMBL9856667 | 0.71 | HTR2A (0.51) | SLC6A9SLC6A4HRH3HTR2AHRH1 | |
| SCHEMBL9857080 | 0.70 | HTR2A (0.50) | SLC6A9SLC6A4HTR2AHRH1CHRM2 | |
| SCHEMBL9856676 | 0.70 | HTR2A (0.53) | SLC6A9SLC6A4HTR2AHRH1CHRM2 | |
| SCHEMBL9856580 | 0.69 | HTR2A (0.43) | SLC6A9SLC6A4HRH3HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0318233-A2 | Improvements in or relating to serotonin and norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |