Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | POLQ | O75417 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | SCN1A | P35498 | 2/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857222 | 0.87 | HTR2A (0.49) | HTR2AHRH1SLC6A4HRH3SLC6A2 | |
| SCHEMBL9857001 | 0.83 | SLC6A4 (0.40) | SLC6A4HRH3SLC6A2UTS2RPPARG | |
| SCHEMBL9856580 | 0.81 | HTR2A (0.43) | HTR2AHRH1SLC6A4HRH3SLC6A2 | |
| SCHEMBL9856513 | 0.81 | TAAR1 (0.53) | HTR2AHRH1SLC6A4HRH3SLC6A2 | |
| SCHEMBL9856925 | 0.80 | HTR2A (0.47) | HTR2AHRH1SLC6A4HRH3SLC6A2 | |
| SCHEMBL9856891 | 0.79 | HTR2A (0.53) | HTR2AHRH1SLC6A4SLC6A2SLC6A9 | |
| SCHEMBL9857086 | 0.79 | HTR2A (0.53) | HTR2AHRH1SLC6A4SLC6A2OPRK1 | |
| SCHEMBL9856563 | 0.78 | TAAR1 (0.53) | HTR2AHRH1SLC6A4HRH3SLC6A2 | |
| SCHEMBL9856826 | 0.78 | TAAR1 (0.53) | HTR2AHRH1SLC6A4HRH3SLC6A2 | |
| SCHEMBL9857350 | 0.77 | SLC6A9 (0.67) | HTR2AHRH1SLC6A4HRH3SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0318233-A2 | Improvements in or relating to serotonin and norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |