Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.44 |
| ▸ | HRH1 | P35367 | 4/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9856889 | 0.86 | TAAR1 (0.53) | HTR2AHRH1TAAR1SLC6A4NOS2 | |
| SCHEMBL9856950 | 0.86 | HTR2A (0.51) | HTR2AHRH1TAAR1SLC6A4NOS2 | |
| SCHEMBL9857236 | 0.82 | HTR2A (0.53) | HTR2AHRH1SLC6A4SLC6A2CYP1A2 | |
| SCHEMBL9857368 | 0.80 | HTR2A (0.47) | HTR2AHRH1SLC6A4SLC6A2CYP1A2 | |
| SCHEMBL14526719 | 0.76 | HTR2A (0.53) | HTR2AHRH1SLC6A4SLC6A2CYP1A2 | |
| SCHEMBL8263713 | 0.76 | HTR2A (0.53) | HTR2AHRH1SLC6A4SLC6A2CYP1A2 | |
| SCHEMBL9856722 | 0.75 | HTR2A (0.51) | HTR2AHRH1SLC6A4SLC6A2CYP1A2 | |
| SCHEMBL9857321 | 0.74 | HTR2A (0.47) | HTR2AHRH1SLC6A4SLC6A2CYP1A2 | |
| SCHEMBL9856916 | 0.73 | HTR2A (0.54) | HTR2AHRH1TAAR1SLC6A4SLC6A2 | |
| SCHEMBL9856174 | 0.73 | L3MBTL1 (0.51) | HTR2AHRH1SLC6A4SLC6A2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |