Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HRH1 | P35367 | 3/20 | 0.51 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SCN1A | P35498 | 2/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9856676 | 0.86 | HTR2A (0.53) | HTR2AHRH1SLC6A9UBE2NSLC6A4 | |
| SCHEMBL9856667 | 0.84 | HTR2A (0.51) | HTR2AHRH1SLC6A9UBE2NSLC6A4 | |
| SCHEMBL9856457 | 0.84 | HTR2A (0.51) | HTR2AHRH1SLC6A9UBE2NSLC6A4 | |
| SCHEMBL9857080 | 0.83 | HTR2A (0.50) | HTR2AHRH1SLC6A9UBE2NSLC6A4 | |
| SCHEMBL9856968 | 0.82 | ALDH1A1 (0.51) | SLC6A4ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9857039 | 0.82 | ALDH1A1 (0.61) | HTR2AHRH1SLC6A9SLC6A4ALDH1A1 | |
| SCHEMBL9857059 | 0.81 | HTR2A (0.47) | HTR2AHRH1SLC6A9UBE2NSLC6A4 | |
| SCHEMBL9857350 | 0.81 | SLC6A9 (0.67) | HTR2AHRH1SLC6A9SLC6A4OPRK1 | |
| SCHEMBL9857068 | 0.80 | SLC6A4 (0.47) | HTR2AHRH1SLC6A9SLC6A4CHRM1 | |
| SCHEMBL9856994 | 0.80 | MEN1 (0.48) | HTR2AHRH1SLC6A9SLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |