Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 3/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.48 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713817 | 0.90 | PLK1 (0.59) | CYSLTR2CYSLTR1PLK1 | |
| SCHEMBL9857033 | 0.88 | NR1H4 (0.63) | SMPD1NR1H4MEN1KMT2ATHRB | |
| SCHEMBL9132501 | 0.87 | PLK1 (0.52) | NR1H4CYSLTR2CYSLTR1PLK1 | |
| SCHEMBL9132741 | 0.87 | PLK1 (0.52) | NR1H4CYSLTR2CYSLTR1PLK1 | |
| SCHEMBL10721101 | 0.82 | NR1H4 (0.59) | NR1H4MEN1KMT2ATP53THRB | |
| SCHEMBL9713298 | 0.81 | SMPD1 (0.60) | SMPD1NR1H4MEN1KMT2ATP53 | |
| SCHEMBL9135604 | 0.80 | CACNA1H (0.49) | NR1H4CYSLTR2CYSLTR1PLK1 | |
| SCHEMBL9255356 | 0.79 | PLK1 (0.44) | MEN1KMT2ACYSLTR2CYSLTR1PLK1 | |
| SCHEMBL9254816 | 0.79 | PLK1 (0.44) | MEN1KMT2ACYSLTR2CYSLTR1PLK1 | |
| SCHEMBL9254823 | 0.78 | CYSLTR2 (0.52) | MEN1KMT2ACYSLTR2CYSLTR1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994479-A | Antagonists of SRS-A(slow reacting substance of anaphylaxis); antiallergens, antiischemic agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| EP-0218728-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |
| WO-1986005779-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-10-09 | — | — | WO | disclosed |