Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19667831 | 0.87 | KDM4E (0.48) | CTSDKDM4EKDM5CPHF8KDM2A | |
| SCHEMBL7749331 | 0.78 | — | — | |
| SCHEMBL9325348 | 0.73 | — | — | |
| SCHEMBL17038880 | 0.73 | — | — | |
| SCHEMBL8257596 | 0.72 | TSHR (0.50) | KDM4EALDH1A1POLBHTTMAPT | |
| SCHEMBL11249999 | 0.71 | — | — | |
| Dimethyl Sulfoxide SCHEMBL28118530 | 0.71 | CTSD (0.52) | CTSDKDM4EKDM5CPHF8KDM2A | |
| SCHEMBL9857497 | 0.71 | CTSD (0.46) | CTSDKDM4EKDM5CPHF8KDM2A | |
| SCHEMBL19682728 | 0.69 | CTSD (0.41) | CTSDKDM4EKDM5CPHF8KDM2A | |
| SCHEMBL924945 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0193822-B1 | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(thio-, sulfinyl- and sulfonyl-containing acyl)hydrazides | G.D. Searle & Co. (US) | 1991-03-20 | — | — | EP | claimed |
| EP-0193822-A2 | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(thio-, sulfinyl- and sulfonyl-containing acyl)hydrazides | G.D. Searle & Co. (US) | 1986-09-10 | — | — | EP | claimed |
| US-4559336-A | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides | G.D. SEARLE & CO. (US) | 1985-12-17 | — | — | US | claimed |
| US-4614617-A | Intermediates for 8-chlorodibenz[(b,f)][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides | G. D. SEARLE & CO. (US) | 1986-09-30 | — | — | US | disclosed |
| US-4559336-A | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides | G.D. SEARLE & CO. (US) | 1985-12-17 | — | — | US | disclosed |