Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1332960 | 0.87 | CYSLTR2 (0.45) | CYSLTR2CYSLTR1TSHRNR1I2PPARG | |
| SCHEMBL6882280 | 0.81 | CYSLTR2 (0.43) | CYSLTR2CYSLTR1PPARGTDP1 | |
| SCHEMBL1880780 | 0.81 | CYSLTR2 (0.40) | CYSLTR2CYSLTR1TSHRTDP1MEN1 | |
| SCHEMBL28702571 | 0.81 | CYSLTR2 (0.43) | CYSLTR2CYSLTR1NR1I2PPARGPRSS1 | |
| SCHEMBL490156 | 0.79 | ALDH1A1 (0.40) | CYSLTR2CYSLTR1PPARGKMT2APRSS1 | |
| SCHEMBL9351919 | 0.79 | CYSLTR2 (0.42) | CYSLTR2CYSLTR1NR1I2PPARGPRSS1 | |
| SCHEMBL1856281 | 0.78 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1NR1I2PPARGTDP1 | |
| SCHEMBL489761 | 0.78 | ALDH1A1 (0.39) | CYSLTR2CYSLTR1PPARGKMT2APRSS1 | |
| SCHEMBL489432 | 0.78 | ALDH1A1 (0.39) | CYSLTR2CYSLTR1PPARGTDP1MEN1 | |
| SCHEMBL8741674 | 0.77 | CYSLTR2 (0.40) | CYSLTR2CYSLTR1NR1I2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0301401-B1 | LEUKOTRIENE ANTAGONISTS, PROCESS FOR THEIR PREPARATION, THEIR USE IN THE TREATMENT OF ILLNESSES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-11-27 | — | — | EP | disclosed |
| EP-0301401-A2 | Leukotriene antagonists, process for their preparation, their use in the treatment of illnesses | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-01 | — | — | EP | disclosed |