Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29873959 | 0.82 | TDP1 (0.41) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL21239472 | 0.82 | TDP1 (0.41) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL11533450 | 0.81 | MAPK1 (0.40) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL29873432 | 0.81 | TDP1 (0.56) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL1879413 | 0.81 | TDP1 (0.56) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL9859216 | 0.74 | CYP3A4 (0.38) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL545529 | 0.73 | DRD1 (0.48) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL12600355 | 0.73 | MAPK1 (0.52) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL9859656 | 0.72 | MAPK1 (0.47) | MAPK1TDP1CYP3A4TRPA1TSHR | |
| SCHEMBL1569276 | 0.70 | DRD1 (0.46) | MAPK1TDP1MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153127-B1 | N-ARYL-3-ARYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDES, PROCESSES FOR THEIR PRODUCTION, INSECTICIDAL COMPOSITIONS CONTAINING THEM AND METHODS FOR COMBATTING INSECTS | ROHM AND HAAS COMPANY (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4863947-A | PESTICIDES, INSECTICIDES | ROHM AND HAAS (US) | 1989-09-05 | — | — | US | disclosed |
| US-4663341-A | Insecticidal n-aryl-3-aryl-4,5-dihydro-1h-pyrazole-1-carboxamides | ROHM AND HAAS COMPANY (US) | 1987-05-05 | — | — | US | disclosed |
| EP-0153127-A2 | N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides, processes for their production, insecticidal compositions containing them and methods for combatting insects | ROHM AND HAAS COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |