Sugi Predict

Sugi Predict / Compounds / SCHEMBL1879413

SCHEMBL1879413

SCHEMBL1879413

O=C=Nc1ccc(OC(F)F)c(Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 2/20 0.56
▸ MAPK1 P28482 1/20 0.56
▸ MAPT P10636 13/20 0.41
▸ MEN1 O00255 11/20 0.41
▸ KMT2A Q03164 11/20 0.41
▸ HTT P42858 8/20 0.41
▸ LMNA P02545 8/20 0.41
▸ ALDH1A1 P00352 7/20 0.41
▸ TP53 P04637 1/20 0.41
▸ HTR1E P28566 1/20 0.41
▸ S1PR3 Q99500 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ SMN1; SMN2 Q16637 4/20 0.39
▸ RAB9A P51151 3/20 0.39
▸ NPSR1 Q6W5P4 2/20 0.39
▸ NPC1 O15118 2/20 0.39
▸ NFKB1 P19838 1/20 0.39
▸ NFKB2 Q00653 1/20 0.39
▸ RELA Q04206 1/20 0.39
▸ POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29873432 1.00 TDP1 (0.56) TDP1MAPK1MAPTMEN1KMT2A
SCHEMBL11532910 0.89 TDP1 (0.54) TDP1MAPK1MAPTMEN1KMT2A
SCHEMBL11804851 0.84 MAPK1 (0.56) TDP1MAPK1MEN1KMT2ALMNA
SCHEMBL25272266 0.84 MAPT (0.42) TDP1MAPK1MAPTMEN1KMT2A
SCHEMBL21239472 0.82 TDP1 (0.41) TDP1MAPK1KMT2AALDH1A1CYP3A4
SCHEMBL29873959 0.82 TDP1 (0.41) TDP1MAPK1KMT2AALDH1A1CYP3A4
SCHEMBL11533450 0.81 MAPK1 (0.40) TDP1MAPK1ALDH1A1CYP3A4TRPA1
SCHEMBL9858893 0.81 MAPK1 (0.40) TDP1MAPK1MEN1KMT2ALMNA
SCHEMBL11336774 0.80 TDP1 (0.51) TDP1MAPK1MAPTMEN1KMT2A
SCHEMBL421340 0.78 TDP1 (0.61) TDP1MAPK1MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109843283-B Urea derivatives 第一三共株式会社 2022-08-30 — — CN disclosed
US-20220144765-A1 UREA DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2022-05-12 — — US disclosed
US-20210206716-A1 UREA DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2021-07-08 — — US disclosed
US-10968169-B2 Urea derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2021-04-06 — — US disclosed
CN-108753220-B High-temperature-resistant and solvent-resistant phenolic resin film 长春峰泰汽车胶业有限公司 2021-01-05 — — CN disclosed
EP-3524240-A1 UREA DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2019-08-14 — — EP disclosed
EP-2091920-B1 SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING THESE, METHOD OF PRODUCTION AND USE SANOFI SA (FR) 2014-10-22 — — EP disclosed
US-8420824-B2 Substituted pyrazoles, compositions containing these, method of production and use SANOFI (FR) 2013-04-16 — — US disclosed
US-8410286-B2 Substituted pyrazoles, compositions containing these, method of production and use SANOFI-AVENTIS (FR) 2013-04-02 — — US disclosed
US-20110237641-A1 SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING THESE, METHOD OF PRODUCTION AND USE SANOFI-AVENTIS (FR) 2011-09-29 — — US disclosed
WO-2005007157-A1 PYRAZOLINES AS PAR-1 ANTAGONISTS FOR TREATMENT OF CARDIOVASCULAR DISEASES BAYER HEALTHCARE AG (DE) 2005-01-27 — — WO disclosed
EP-0153127-B1 N-ARYL-3-ARYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDES, PROCESSES FOR THEIR PRODUCTION, INSECTICIDAL COMPOSITIONS CONTAINING THEM AND METHODS FOR COMBATTING INSECTS ROHM AND HAAS COMPANY (US) 1991-04-03 — — EP disclosed
US-4863947-A PESTICIDES, INSECTICIDES ROHM AND HAAS (US) 1989-09-05 — — US disclosed
US-4663341-A Insecticidal n-aryl-3-aryl-4,5-dihydro-1h-pyrazole-1-carboxamides ROHM AND HAAS COMPANY (US) 1987-05-05 — — US disclosed
EP-0153127-A2 N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides, processes for their production, insecticidal compositions containing them and methods for combatting insects ROHM AND HAAS COMPANY (US) 1985-08-28 — — EP disclosed
US-4465682-A Combating pests with substituted 3,6-diphenyl-3,4-dihydro-2H-1,3,5-oxadiazine-2,4-diones BAYER AKTIENGESELLSCHAFT (DE) 1984-08-14 — — US disclosed
US-4348394-A Combating pests with substituted 3,6-diphenyl-3,4-dihydro-2H-1,3,5-oxadiazine-2,4-diones BAYER AKTIENGESELLSCHAFT (DE) 1982-09-07 — — US disclosed
EP-0014881-B1 OXADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES BAYER AG (DE) 1982-02-17 — — EP disclosed
EP-0014881-A1 Oxadiazine derivatives, process for their preparation and their use as pesticides BAYER AG (DE) 1980-09-03 — — EP disclosed
US-4140792-A INSECTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1979-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210206716-A1 UREA DERIVATIVE IDO1, IDO2, TPH1 TDP1 3072/4885MAPK1 2597/4885MAPT 1133/4885
US-10968169-B2 Urea derivative IDO1, IDO2, UTS2R TDP1 3022/4885MAPK1 2770/4885MAPT 1010/4885
US-20220144765-A1 UREA DERIVATIVE IDO1, IDO2, TPH1 TDP1 3072/4885MAPK1 2597/4885MAPT 1133/4885
US-20110237641-A1 SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING THESE, METHOD OF PRODUCTION AND USE ADORA3, ADORA2B, CYP4B1 TDP1 1350/4885MAPK1 1952/4885MAPT 2805/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.