Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1742147 | 0.89 | RAB9A (0.66) | RAB9AMAPTSMN1; SMN2TDP1KMT2A | |
| SCHEMBL11178851 | 0.86 | RAB9A (0.67) | RAB9AMAPTSMN1; SMN2TDP1KMT2A | |
| SCHEMBL2208811 | 0.86 | RAB9A (0.58) | RAB9AMAPTSMN1; SMN2TDP1KMT2A | |
| SCHEMBL17273619 | 0.85 | RAB9A (0.60) | RAB9AMAPTSMN1; SMN2TDP1KMT2A | |
| SCHEMBL30602605 | 0.85 | RAB9A (0.60) | RAB9AMAPTSMN1; SMN2TDP1KMT2A | |
| SCHEMBL9127589 | 0.84 | RAB9A (0.63) | RAB9AMAPTSMN1; SMN2TDP1KMT2A | |
| SCHEMBL9872622 | 0.83 | RAB9A (0.62) | RAB9AMAPTSMN1; SMN2TDP1KMT2A | |
| SCHEMBL18732030 | 0.83 | RAB9A (0.62) | RAB9AMAPTSMN1; SMN2TDP1KMT2A | |
| Hydrochloric Acid SCHEMBL9125718 | 0.83 | RAB9A (0.62) | RAB9AMAPTSMN1; SMN2TDP1KMT2A | |
| Dimethylamine SCHEMBL9871927 | 0.83 | MAPT (0.62) | RAB9AMAPTSMN1; SMN2TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988828-A | Antiulcer agents, antagonist for histamine H2 receptors | FUJIREBIO KABUSHIKI KAISHA (JP) | 1991-01-29 | — | — | US | disclosed |
| EP-0318036-A2 | Phenoxypropyl derivatives | FUJIREBIO KABUSHIKI KAISHA (JP) | 1989-05-31 | — | — | EP | disclosed |
| US-4738960-A | 1,3,4-Thiadiazole derivatives and pharmaceutical preparations useful as inhibitors for histamine-H2 receptors | LUDWIG HEUMANN & CO. GMBH (DE) | 1988-04-19 | — | — | US | disclosed |
| EP-0197189-A2 | 1,3,4-Thiadiazole derivatives, process for their preparation and medicines containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1986-10-15 | — | — | EP | disclosed |
| EP-0002930-B1 | AMINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1983-12-14 | — | — | EP | disclosed |
| EP-0024510-B1 | PHENOXYPROPYL AMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1983-10-19 | — | — | EP | disclosed |
| US-4304780-A | Aminoalkylthiophene derivatives as histamine H2 -antagonists | GLAXO GROUP LIMITED (GB) | 1981-12-08 | — | — | US | disclosed |
| US-4293557-A | AMIDES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1981-10-06 | — | — | US | disclosed |
| US-4279911-A | ANTIHISTAMINES | GLAXO GROUP LIMITED (GB) | 1981-07-21 | — | — | US | disclosed |
| EP-0024510-A1 | Phenoxypropyl amine derivatives, process for their preparation, and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1981-03-11 | — | — | EP | disclosed |
| US-4233302-A | ANTIHISTAMINES, ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1980-11-11 | — | — | US | disclosed |
| EP-0002930-A1 | Amine derivatives, their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1979-07-11 | — | — | EP | disclosed |