SCHEMBL986053

SCHEMBL986053

O=C(C1CC1)C(Cl)c1ccccc1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.41
CES1 P23141 2/20 0.41
NOTUM Q6P988 1/20 0.39
OPRM1 P35372 2/20 0.38
ABCB11 O95342 1/20 0.38
CHRM2 P08172 1/20 0.38
ADORA3 P0DMS8 1/20 0.38
AR P10275 1/20 0.38
P2RY12 Q9H244 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
GAA P10253 2/20 0.37
ALDH1A1 P00352 2/20 0.37
CYP3A4 P08684 1/20 0.37
MAPT P10636 1/20 0.37
CYP2C9 P11712 1/20 0.37
CNR2 P34972 2/20 0.36
POLB P06746 1/20 0.36
ALOX15 P16050 1/20 0.36
RIPK1 Q13546 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12126396 0.81 CES2 (0.54) CES2CES1NOTUMOPRM1ABCB11
SCHEMBL12809865 0.81 CES2 (0.54) CES2CES1NOTUMOPRM1ABCB11
SCHEMBL12675876 0.79 CES2 (0.38) CES2CES1OPRM1MEN1KMT2A
SCHEMBL13287436 0.79 KMT2A (0.33) NOTUMOPRM1MEN1KMT2AGAA
SCHEMBL10005655 0.79 HIF1A (0.46) CES2CES1NOTUMOPRM1ABCB11
SCHEMBL3318078 0.79 CES2 (0.41) CES2CES1NOTUMOPRM1ABCB11
SCHEMBL242256 0.79 CES2 (0.41) CES2CES1NOTUMOPRM1ABCB11
SCHEMBL1285812 0.76 CES2 (0.47) CES2CES1MEN1KMT2AGAA
SCHEMBL1885454 0.76 CES2 (0.47) CES2CES1MEN1KMT2AGAA
SCHEMBL28080811 0.76 KCNQ2 (0.47) CES2CES1NOTUMOPRM1ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8193358-B2 Process for producing high-purity prasugrel and acid addition salt thereof DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-06-05 US claimed
WO-2012052788-A1 METHOD FOR PREPARING PHARMACEUTICALLY ACTIVE INGREDIENT AND INTERMEDIATES THEREOF EGIS GYÓGYSZERGYÁR NYILVÁNOSAN MŰKÖDŐ RÉSZVÉNYTÁRSASÁG (HU) 2012-04-26 WO claimed
EP-0785205-B1 2-SILYLOXYTETRAHYDROTHIENOPYRIDINE, SALT THEREOF, AND PROCESS FOR PRODUCING THE SAME UBE INDUSTRIES (JP) 2002-04-17 EP claimed
US-5874581-A CHEMICAL INTERMEDIATE OF AN ANTIPLATELET MEDICINE AND AN ELASTASE INHIBITOR; REACTING A HALOSILANE AND A 2-OXO-4,5,6,7 -TETRAHYDROTHIENO(3,2-C)PYRIDINE IN THE PRESENCE OF A TERTIARY AMINE UBE INDUSTRIES, LTD. (JP) 1999-02-23 US claimed
EP-0785205-A1 2-SILYLOXYTETRAHYDROTHIENOPYRIDINE, SALT THEREOF, AND PROCESS FOR PRODUCING THE SAME UBE INDUSTRIES, LTD. (JP) 1997-07-23 EP claimed
EP-2003136-B1 PROCESS FOR PRODUCING HIGH-PURITY PRASUGREL HYDROCHLORIDE DAIICHI SANKYO CO LTD (JP) 2017-01-18 EP disclosed
EP-2471795-B1 METHOD FOR PREPARING PRASUGREL ZHEJIANG HUAHAI PHARM CO LTD (CN) 2016-04-20 EP disclosed
US-9169265-B2 Process for preparing pharmaceutical compounds and intermediate compounds EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (HU) 2015-10-27 US disclosed
US-9169265-B2 Process for preparing pharmaceutical compounds and intermediate compounds EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (HU) 2015-10-27 US disclosed
US-9169265-B2 Process for preparing pharmaceutical compounds and intermediate compounds EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (HU) 2015-10-27 US disclosed
US-8937053-B2 Process for the preparation of prasugrel and several novel crystalline forms of prasugrel hydrochloride SUNSHINE LAKE PHARMA CO., LTD. (CN) 2015-01-20 US disclosed
US-8937053-B2 Process for the preparation of prasugrel and several novel crystalline forms of prasugrel hydrochloride SUNSHINE LAKE PHARMA CO., LTD. (CN) 2015-01-20 US disclosed
CN-101486635-A Preparation of alpha-cyclopropyl carbonyl-2-benzyl-fluorobenzyl halogen SHANGHAI INST PHARM INDUSTRY (CN) 2009-07-22 CN disclosed
WO-2009068924-A1 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL I NTERM EDIATES EGIS GYÓGYSZERGYÁR NYILVÁNOSAN MÜKÖDÖ (HU) 2009-06-04 WO disclosed
WO-2009062044-A2 PROCESSES FOR THE PREPARATION OF PRASUGREL, AND ITS SALTS AND POLYMORPHS DR. REDDY'S LABORATORIES LTD. (IN) 2009-05-14 WO disclosed
WO-2009062044-A2 PROCESSES FOR THE PREPARATION OF PRASUGREL, AND ITS SALTS AND POLYMORPHS DR. REDDY'S LABORATORIES LTD. (IN) 2009-05-14 WO disclosed
EP-2003136-A1 PROCESS FOR PRODUCING HIGH-PURITY PRASUGREL AND ACID ADDITION SALT THEREOF Daiichi Sankyo Company, Limited (JP) 2008-12-17 EP disclosed
EP-0785205-B1 2-SILYLOXYTETRAHYDROTHIENOPYRIDINE, SALT THEREOF, AND PROCESS FOR PRODUCING THE SAME UBE INDUSTRIES (JP) 2002-04-17 EP disclosed
US-5874581-A CHEMICAL INTERMEDIATE OF AN ANTIPLATELET MEDICINE AND AN ELASTASE INHIBITOR; REACTING A HALOSILANE AND A 2-OXO-4,5,6,7 -TETRAHYDROTHIENO(3,2-C)PYRIDINE IN THE PRESENCE OF A TERTIARY AMINE UBE INDUSTRIES, LTD. (JP) 1999-02-23 US disclosed
EP-0785205-A1 2-SILYLOXYTETRAHYDROTHIENOPYRIDINE, SALT THEREOF, AND PROCESS FOR PRODUCING THE SAME UBE INDUSTRIES, LTD. (JP) 1997-07-23 EP disclosed