Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | HTT | P42858 | 5/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | TDP2 | O95551 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9976765 | 0.85 | KDM4E (0.66) | KDM4EHTTHSP90AA1TDP1TP53 | |
| SCHEMBL22117512 | 0.82 | MAPT (0.54) | KDM4EHTTHSP90AA1TDP1TP53 | |
| SCHEMBL27934157 | 0.78 | MEN1 (0.58) | KDM4EHTTHSP90AA1TDP1TP53 | |
| SCHEMBL22117517 | 0.78 | KDM4E (0.58) | KDM4EHTTHSP90AA1TDP1TP53 | |
| SCHEMBL18935217 | 0.78 | KDM4E (0.49) | KDM4EHTTHSP90AA1TDP1TP53 | |
| SCHEMBL3711428 | 0.78 | KDM4E (0.45) | KDM4EHTTHSP90AA1TDP1TP53 | |
| SCHEMBL29551392 | 0.78 | HTT (0.52) | KDM4EHTTHSP90AA1TDP1TP53 | |
| SCHEMBL4470656 | 0.78 | HTT (0.52) | KDM4EHTTHSP90AA1TDP1TP53 | |
| SCHEMBL1149641 | 0.76 | L3MBTL1 (0.61) | KDM4EHTTHSP90AA1TDP1TP53 | |
| SCHEMBL8654916 | 0.76 | CCR1 (0.61) | KDM4EHTTHSP90AA1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818739-B | Metal iridium complex with synergistic response to tumor microenvironment pH/hypoxic and application thereof | 南京大学 | 2021-05-28 | — | — | CN | disclosed |
| CN-110857310-B | Polyamphidine ruthenium complex with photoactivity and application thereof | 南京大学 | 2021-05-28 | — | — | CN | disclosed |
| CN-110857310-A | Polyamphidine ruthenium complex with photoactivity and application thereof | 南京大学 | 2020-03-03 | — | — | CN | disclosed |
| CN-110818739-A | Metal iridium complex with synergistic response to tumor microenvironment pH/hypoxic and application thereof | 南京大学 | 2020-02-21 | — | — | CN | disclosed |
| US-5070158-A | Covalently labeled siloxane polymers | HEWLETT-PACKARD COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| EP-0283206-A2 | Covalently labeled siloxane polymers | Hewlett-Packard Company (US) | 1988-09-21 | — | — | EP | disclosed |