SCHEMBL9861498

SCHEMBL9861498

O=C1C=CC(O[Si](c2ccccc2)(c2ccccc2)c2ccccc2)(C(F)(F)F)C=C1

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR9 Q9NR96 1/20 0.30
SMYD2 Q9NRG4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9861373 0.77 TLR9 (0.37) TLR9
SCHEMBL9339535 0.74 TP53 (0.36)
SCHEMBL9314843 0.70 TP53 (0.31)
SCHEMBL9861371 0.66 MEN1 (0.30)
SCHEMBL4274822 0.62 CES1 (0.43)
SCHEMBL9861393 0.61 TP53 (0.34)
SCHEMBL7727762 0.60 TSHR (0.35)
SCHEMBL9899243 0.59 KDM4E (0.32)
SCHEMBL537935 0.59 CA2 (0.36)
SCHEMBL1053099 0.57 CES1 (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5008425-A Trifluoromethylation of carbonyl compounds ETHYL CORPORATION (US) 1991-04-16 US disclosed
US-4845258-A Production of gem-disubstituted cyclohexadienones ETHYL CORPORATION (US) 1989-07-04 US disclosed
US-4804774-A Production of gem-disubstituted cyclohexadienones ETHYL CORPORATION (US) 1989-02-14 US disclosed
US-4804772-A Gem-disubstituted cyclohexadienones and their production ETHYL CORPORATION (US) 1989-02-14 US disclosed
US-4804773-A Production of gem-disubstituted cyclohexadienones ETHYL CORPORATION (US) 1989-02-14 US disclosed