SCHEMBL9861862

SCHEMBL9861862

O=C1CCCC(=O)C1c1cccc2c1CCCC2

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.44
BAD Q92934 1/20 0.44
TBXA2R P21731 1/20 0.39
ANPEP P15144 2/20 0.38
TSHR P16473 1/20 0.37
POLB P06746 1/20 0.36
CYP2A6 P11509 1/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
ALDH1A1 P00352 1/20 0.36
RXRA P19793 3/20 0.35
RXRB P28702 3/20 0.35
RXRG P48443 3/20 0.35
TAS1R3 Q7RTX0 1/20 0.35
TAS1R1 Q7RTX1 1/20 0.35
TAS1R2 Q8TE23 1/20 0.35
IDO1 P14902 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18828495 0.73 HTR1A (0.50) BCL2L1BADTAS1R3TAS1R1TAS1R2
SCHEMBL21590061 0.70 HTR1A (0.55) BCL2L1BADTSHRTAS1R3TAS1R1
SCHEMBL30285578 0.70 HTR1A (0.55) BCL2L1BADTSHRTAS1R3TAS1R1
SCHEMBL21733468 0.70 HTR1A (0.44) BCL2L1BADALDH1A1TAS1R3TAS1R1
SCHEMBL6768377 0.68 BCL2L1 (0.38) BCL2L1BADTBXA2RTSHRALDH1A1
SCHEMBL10736168 0.68 TP53 (0.47) TSHRPOLBALDH1A1
SCHEMBL19706412 0.68 HTR2C (0.55) MAOB
SCHEMBL29209214 0.68 GID4 (0.50) BCL2L1BADTSHRALDH1A1TAS1R3
SCHEMBL30186198 0.68 GID4 (0.50) BCL2L1BADTSHRALDH1A1TAS1R3
SCHEMBL21733883 0.67 NISCH (0.37) BCL2L1BADTBXA2RALDH1A1TAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0176294-B1 CYCLOHEXANE-1,3-DIONE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PROCESSES FOR PREPARING THEM, AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS ICI AUSTRALIA LIMITED (AU) 1991-06-05 EP disclosed
US-4639267-A Herbicidal cyclohexane-1,3-dione derivatives ICI AUSTRALIA LIMITED (AU) 1987-01-27 US disclosed
EP-0176294-A1 Cyclohexane-1,3-dione derivatives, compositions containing them, processes for preparing them, and their use as herbicides and plant growth regulators ICI AUSTRALIA LIMITED (AU) 1986-04-02 EP disclosed