Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL28861660 | 0.82 | LMNA (0.44) | TSHRALDH1A1KDM4EHSD17B10ALOX15 | |
| SCHEMBL1352722 | 0.81 | NOTUM (0.48) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL30675636 | 0.81 | NOTUM (0.48) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL25044297 | 0.80 | LMNA (0.46) | TSHRALDH1A1KDM4EHSD17B10ALOX15 | |
| SCHEMBL5666504 | 0.80 | ALDH1A1 (0.46) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL16961186 | 0.80 | — | — | |
| SCHEMBL688471 | 0.79 | ALDH1A1 (0.56) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| Benzene SCHEMBL29290216 | 0.79 | ALDH1A1 (0.56) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| Benzene SCHEMBL27265959 | 0.79 | TSHR (0.61) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL756585 | 0.79 | TSHR (0.61) | TSHRALDH1A1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12351570-B2 | Disubstituted alkyne derivatives | MERCK PATENT GMBH (DE) | 2025-07-08 | — | — | US | disclosed |
| EP-4324833-A1 | ALKYNYLPHENYLBENZAMIDE COMPOUND AND USE THEREOF | Shenzhen Newdel Biotech Co., Ltd. (CN) | 2024-02-21 | — | — | EP | disclosed |
| US-11834454-B2 | Alkynylphenylbenzamide compounds and applications thereof | SHENZHEN NEWDEL BIOTECH CO., LTD. (CN) | 2023-12-05 | — | — | US | disclosed |
| US-11834454-B2 | Alkynylphenylbenzamide compounds and applications thereof | SHENZHEN NEWDEL BIOTECH CO., LTD. (CN) | 2023-12-05 | — | — | US | disclosed |
| US-11834454-B2 | Alkynylphenylbenzamide compounds and applications thereof | SHENZHEN NEWDEL BIOTECH CO., LTD. (CN) | 2023-12-05 | — | — | US | disclosed |
| CN-116693414-A | Compound with 3CL protease inhibition activity and application thereof | 深圳市小分子新药创新中心有限公司 | 2023-09-05 | — | — | CN | disclosed |
| US-20230046126-A1 | ALKYNYLPHENYLBENZAMIDE COMPOUNDS AND APPLICATIONS THEREOF | SHENZHEN NEWDEL BIOTECH CO., LTD. (CN) | 2023-02-16 | — | — | US | disclosed |
| US-20230046126-A1 | ALKYNYLPHENYLBENZAMIDE COMPOUNDS AND APPLICATIONS THEREOF | SHENZHEN NEWDEL BIOTECH CO., LTD. (CN) | 2023-02-16 | — | — | US | disclosed |
| US-20230052586-A1 | DISUBSTITUTED ALKYNE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-02-16 | — | — | US | disclosed |
| EP-3898588-B1 | DISUBSTITUTED ALKYNE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-01-11 | — | — | EP | disclosed |
| WO-2022217821-A1 | ALKYNYLPHENYLBENZAMIDE COMPOUND AND USE THEREOF | 深圳市新樾生物科技有限公司 | 2022-10-20 | — | — | WO | disclosed |
| CN-113831344-B | Propargyl phenyl benzamide compound and application thereof | 深圳市新樾生物科技有限公司 | 2022-09-16 | — | — | CN | disclosed |
| CN-113831344-A | Propargyl phenyl benzamide compound and application thereof | 暨南大学 | 2021-12-24 | — | — | CN | disclosed |
| WO-2021249969-A1 | COMBINATION PRODUCT FOR THE TREATMENT OF CANCER DISEASES | MERCK PATENT GMBH (DE) | 2021-12-16 | — | — | WO | disclosed |
| EP-3898588-A1 | DISUBSTITUTED ALKYNE DERIVATIVES | Merck Patent GmbH (DE) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020127960-A1 | DISUBSTITUTED ALKYNE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-25 | — | — | WO | disclosed |
| WO-1991009066-A1 | HIGH CARBON RESINS AND FOAMS | HYPERION CATALYSIS INTERNATIONAL, INC. (US) | 1991-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230046126-A1 | ALKYNYLPHENYLBENZAMIDE COMPOUNDS AND APPLICATIONS THEREOF | ALK, NTRK1, ERBB2 | TSHR 759/4885ALDH1A1 972/4885HPGD 3179/4885 |
| US-12351570-B2 | Disubstituted alkyne derivatives | BRCA1, MYC, PCNA | TSHR 3500/4885ALDH1A1 414/4885HPGD 745/4885 |
| US-11834454-B2 | Alkynylphenylbenzamide compounds and applications thereof | ALK, NTRK1, ERBB2 | TSHR 759/4885ALDH1A1 972/4885HPGD 3179/4885 |
| US-20230052586-A1 | DISUBSTITUTED ALKYNE DERIVATIVES | BRCA1, MYC, PCNA | TSHR 3500/4885ALDH1A1 414/4885HPGD 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.