SCHEMBL9862906

SCHEMBL9862906

CC(=O)OC(C#N)c1cccc(Oc2ccccc2)c1

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.59
TDP1 Q9NUW8 1/20 0.59
PTGS1 P23219 1/20 0.55
MEN1 O00255 1/20 0.53
CYP2D6 P10635 1/20 0.53
KMT2A Q03164 1/20 0.53
ALOX5 P09917 2/20 0.51
AKR1C3 P42330 1/20 0.46
ACACB O00763 1/20 0.43
ACACA Q13085 1/20 0.43
HDAC8 Q9BY41 1/20 0.42
ATM Q13315 1/20 0.41
NPY5R Q15761 1/20 0.40
CYP3A4 P08684 1/20 0.40
TLR4 O00206 1/20 0.40
TLR2 O60603 1/20 0.40
GLI1 P08151 1/20 0.40
GLI2 P10070 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9863162 1.00 ALDH1A1 (0.59) ALDH1A1TDP1PTGS1MEN1CYP2D6
SCHEMBL10397026 1.00 ALDH1A1 (0.59) ALDH1A1TDP1PTGS1MEN1CYP2D6
SCHEMBL9078621 0.89 ALDH1A1 (0.53) ALDH1A1TDP1PTGS1MEN1CYP2D6
SCHEMBL15151142 0.86 PTGS1 (0.58) ALDH1A1TDP1PTGS1MEN1CYP2D6
SCHEMBL9863147 0.85 ALDH1A1 (0.55) ALDH1A1TDP1PTGS1MEN1CYP2D6
SCHEMBL9863148 0.85 ALDH1A1 (0.55) ALDH1A1TDP1PTGS1MEN1CYP2D6
SCHEMBL7699172 0.83 ALDH1A1 (0.50) ALDH1A1TDP1MEN1CYP2D6KMT2A
SCHEMBL2835326 0.83 ALDH1A1 (0.50) ALDH1A1TDP1MEN1CYP2D6KMT2A
SCHEMBL10992657 0.83 ALDH1A1 (0.54) ALDH1A1TDP1PTGS1MEN1CYP2D6
SCHEMBL11238071 0.83 ALDH1A1 (0.54) ALDH1A1TDP1PTGS1MEN1CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4234505-A Process for preparing cyanohydrin esters STAUFFER CHEMICAL COMPANY (US) 1980-11-18 US claimed
US-4985365-A WITH AN ESTERASE FROM A MICROORGANISM, ASSYMETRIC HYDROLYSIS SUMITOMO CHEMICAL COMPANY, LTD. (JP) 1991-01-15 US disclosed
US-4897357-A ASYMMETRIC HYDROLYSIS OF RACEMIC MIXTURE USING MICROORGANISM-PRODUCED ENZYME ETHYL CORPORATION (US) 1990-01-30 US disclosed
US-4827013-A (S) α-(cyano-3-phenoxy-benzyl acetate ETHYL CORPORATION (US) 1989-05-02 US disclosed
EP-0080827-B1 METHOD FOR BIOTECHNOLOGICALLY PREPARING (S)-(-)-ALPHA-CYANO-3-PHENOXYBENZYL ALCOHOL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1988-03-09 EP disclosed
EP-0230599-A1 (S) Alpha-cyano-3-phenoxy benzyl acetate ETHYL CORPORATION (US) 1987-08-05 EP disclosed
EP-0080827-A2 Method for biotechnologically preparing (S)-(-)-alpha-cyano-3-phenoxybenzyl alcohol SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-06-08 EP disclosed
US-4234506-A Process for preparing cyanohydrin esters STAUFFER CHEMICAL COMPANY (US) 1980-11-18 US disclosed
US-4234505-A Process for preparing cyanohydrin esters STAUFFER CHEMICAL COMPANY (US) 1980-11-18 US disclosed
US-4234507-A Process for preparing cyanohydrin esters STAUFFER CHEMICAL COMPANY (US) 1980-11-18 US disclosed
US-4234508-A Process for preparing cyanohydrin esters STAUFFER CHEMICAL COMPANY (US) 1980-11-18 US disclosed