Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8603249 | 0.86 | NOTUM (0.54) | NOTUMNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL9864525 | 0.82 | MAPT (0.36) | NOTUMNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL10475736 | 0.78 | NOTUM (0.63) | NOTUMNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL9327094 | 0.77 | SMN1; SMN2 (0.45) | NOTUMNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL8864052 | 0.77 | MAPT (0.43) | MAPTHTTALDH1A1 | |
| SCHEMBL9863333 | 0.76 | MAPT (0.49) | NPC1RAB9ATDP1POLBLMNA | |
| SCHEMBL805128 | 0.75 | NOTUM (0.68) | NOTUMNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL10503546 | 0.75 | NPC1 (0.54) | NOTUMNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL9863656 | 0.75 | NOTUM (0.51) | NOTUMNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL11397475 | 0.75 | MAPT (0.44) | NPC1RAB9AL3MBTL1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041567-A | Human and veterianary medicine; veneral diseases respiratory diseases, bovine mastitis | BEECHAM GROUP PLC (GB) | 1991-08-20 | — | — | US | disclosed |
| US-4812470-A | Antibacterial monic acid derivatives | BEECHAM GROUP P.L.C. (GB) | 1989-03-14 | — | — | US | disclosed |
| EP-0087953-B1 | ANTIBACTERIAL 1-NORMON-2-YL-HETEROCYCLIC COMPOUNDS | BEECHAM GROUP PLC (GB) | 1988-04-27 | — | — | EP | disclosed |
| EP-0087953-A2 | Antibacterial 1-normon-2-yl-heterocyclic compounds | BEECHAM GROUP PLC (GB) | 1983-09-07 | — | — | EP | disclosed |