Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411277 | 0.79 | PARP1 (0.54) | PARP1FAAHHDAC8HDAC6ACHE | |
| SCHEMBL9528530 | 0.79 | PARP1 (0.54) | PARP1FAAHHDAC8HDAC6ACHE | |
| SCHEMBL5271264 | 0.78 | HPGD (0.50) | PARP1FAAHHDAC8HDAC6ACHE | |
| SCHEMBL2092812 | 0.77 | PARP1 (0.69) | PARP1HDAC8HDAC6ACHESMN1; SMN2 | |
| SCHEMBL2163770 | 0.77 | PARP1 (0.57) | PARP1FAAHHDAC8HDAC6ACHE | |
| SCHEMBL10802540 | 0.77 | PARP1 (0.52) | PARP1FAAHHDAC8HDAC6ACHE | |
| SCHEMBL1435772 | 0.77 | PARP1 (0.63) | PARP1FAAHHDAC8HDAC6ACHE | |
| SCHEMBL1793374 | 0.76 | PARP1 (0.56) | PARP1FAAHHDAC8HDAC6ACHE | |
| SCHEMBL11555893 | 0.76 | PARP1 (0.50) | PARP1FAAHHDAC8HDAC6ACHE | |
| SCHEMBL610252 | 0.74 | PARP1 (0.54) | PARP1FAAHHDAC8HDAC6ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041567-A | Human and veterianary medicine; veneral diseases respiratory diseases, bovine mastitis | BEECHAM GROUP PLC (GB) | 1991-08-20 | — | — | US | disclosed |
| US-4812470-A | Antibacterial monic acid derivatives | BEECHAM GROUP P.L.C. (GB) | 1989-03-14 | — | — | US | disclosed |
| EP-0087953-B1 | ANTIBACTERIAL 1-NORMON-2-YL-HETEROCYCLIC COMPOUNDS | BEECHAM GROUP PLC (GB) | 1988-04-27 | — | — | EP | disclosed |
| EP-0087953-A2 | Antibacterial 1-normon-2-yl-heterocyclic compounds | BEECHAM GROUP PLC (GB) | 1983-09-07 | — | — | EP | disclosed |