SCHEMBL1411277

SCHEMBL1411277

Cc1cccc(C(O)=S)c1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.54
FAAH O00519 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.52
ACHE P22303 2/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
POLB P06746 3/20 0.48
MAPT P10636 2/20 0.46
ALDH1A1 P00352 1/20 0.46
RAB9A P51151 1/20 0.46
MEN1 O00255 2/20 0.46
KCNK3 O14649 2/20 0.46
KMT2A Q03164 2/20 0.46
KCNK9 Q9NPC2 2/20 0.46
HPGD P15428 2/20 0.46
KCNH2 Q12809 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
CTDSP1 Q9GZU7 1/20 0.44
CYP1A2 P05177 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11827146 0.82 PRSS1 (0.46) FAAHSMN1; SMN2POLBALDH1A1RAB9A
SCHEMBL2334225 0.82 L3MBTL1 (0.48) MAPTALDH1A1MEN1KMT2AHPGD
SCHEMBL9528530 0.81 PARP1 (0.54) PARP1FAAHSMN1; SMN2ACHEHDAC8
Thiobenzoic Acid SCHEMBL28198923 0.80 LMNA (0.58) SMN1; SMN2ACHEPOLBMAPTALDH1A1
Thiobenzoic Acid SCHEMBL29087094 0.80 KCNK3 (0.46) FAAHSMN1; SMN2POLBMAPTALDH1A1
SCHEMBL1435772 0.79 PARP1 (0.63) PARP1FAAHSMN1; SMN2ACHEHDAC8
SCHEMBL9863444 0.79 PARP1 (0.57) PARP1FAAHSMN1; SMN2ACHEHDAC8
SCHEMBL10802540 0.79 PARP1 (0.52) PARP1FAAHSMN1; SMN2ACHEHDAC8
SCHEMBL2163770 0.79 PARP1 (0.57) PARP1FAAHSMN1; SMN2ACHEHDAC8
SCHEMBL16955311 0.78 PARP1 (0.56) PARP1FAAHSMN1; SMN2ACHEHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240336575-A1 POLYTHIOL COMPOUNDS AND PROCESS FOR PREPARATION THEREOF HENKEL AG & CO KGAA (DE) 2024-10-10 US claimed
US-20240336740-A1 POLYTHIOL COMPOUNDS AND PROCESS FOR PREPARATION THEREOF HENKEL AG & CO KGAA (DE) 2024-10-10 US claimed
US-20240327341-A1 POLYTHIOL COMPOUNDS AND PROCESS FOR PREPARATION THEREOF HENKEL AG & CO KGAA (DE) 2024-10-03 US claimed
CN-118401498-A Polythiol compound and process for producing the same 汉高股份有限及两合公司 2024-07-26 CN claimed
CN-118401566-A Polythiol compound and process for producing the same 汉高股份有限及两合公司 2024-07-26 CN claimed
EP-4198028-B1 POLYTHIOL COMPOUNDS AND PROCESS FOR PREPARATION THEREOF HENKEL AG & CO KGAA (DE) 2024-07-17 EP claimed
EP-4198062-B1 POLYTHIOL COMPOUNDS AND PROCESS FOR PREPARATION THEREOF HENKEL AG & CO KGAA (DE) 2024-07-17 EP claimed
CN-112521240-B Synthesis method of asymmetric thioether 扬州大学 2023-06-30 CN claimed
WO-2023110271-A1 POLYTHIOL COMPOUNDS AND PROCESS FOR PREPARATION THEREOF HENKEL AG & CO. KGAA (DE) 2023-06-22 WO claimed
WO-2023110270-A1 POLYTHIOL COMPOUNDS AND PROCESS FOR PREPARATION THEREOF HENKEL AG & CO. KGAA (DE) 2023-06-22 WO claimed
EP-4198028-A1 POLYTHIOL COMPOUNDS AND PROCESS FOR PREPARATION THEREOF Henkel AG & Co. KGaA (DE) 2023-06-21 EP claimed
EP-4198018-A1 POLYTHIOL COMPOUNDS AND PROCESS FOR PREPARATION THEREOF Henkel AG & Co. KGaA (DE) 2023-06-21 EP claimed
EP-4198062-A1 POLYTHIOL COMPOUNDS AND PROCESS FOR PREPARATION THEREOF Henkel AG & Co. KGaA (DE) 2023-06-21 EP claimed
CN-109422547-A A kind of method of zirconia ceramics surface metalation 北京中科华正电气有限公司 2019-03-05 CN claimed
EP-2699606-B1 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORP (JP) 2016-09-28 EP claimed
EP-2699606-A2 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP Bridgestone Corporation (JP) 2014-02-26 EP claimed
US-20140018500-A1 Polymers Functionalized With A Carboxylic Or Thiocarboxylic Ester Containing A Silylated Amino Group BRIDGESTONE CORPORATION (JP) 2014-01-16 US claimed
WO-2012135451-A2 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2012-10-04 WO claimed
US-20110184173-A1 Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity THE KITASATO INSTITUTE (JP) 2011-07-28 US claimed
EP-2228376-A1 PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY The Kitasato Institute (JP) 2010-09-15 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110184173-A1 Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity ACAT2, ACAT1, AGPAT2 PARP1 4377/4885FAAH 991/4885SMN1; SMN2 4717/4885
US-20240336575-A1 POLYTHIOL COMPOUNDS AND PROCESS FOR PREPARATION THEREOF VRK2, VRK1, PTMS PARP1 1727/4885FAAH 927/4885SMN1; SMN2 4035/4885
US-20240327341-A1 POLYTHIOL COMPOUNDS AND PROCESS FOR PREPARATION THEREOF VCL, C9, VRK1 PARP1 136/4885FAAH 646/4885SMN1; SMN2 4422/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.