Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11384016 | 0.85 | NPC1 (0.41) | MAPTHTTNPC1RAB9ARECQL | |
| SCHEMBL27400700 | 0.78 | MAPT (0.36) | MAPTHTTMEN1KMT2ATSHR | |
| SCHEMBL9863656 | 0.76 | NOTUM (0.51) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11397475 | 0.75 | MAPT (0.44) | MAPTHTTNPC1RAB9ATSHR | |
| SCHEMBL23714048 | 0.74 | TP53 (0.45) | MAPTHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5051561 | 0.74 | MAPT (0.42) | MAPTHTTMEN1KMT2ATSHR | |
| SCHEMBL9863333 | 0.73 | MAPT (0.49) | MAPTHTTNPC1RAB9AALDH1A1 | |
| SCHEMBL10250866 | 0.73 | RAB9A (0.47) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23713981 | 0.72 | TSHR (0.39) | MAPTHTTTP53TSHRMAPK1 | |
| SCHEMBL11387029 | 0.72 | MAPT (0.42) | MAPTHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041567-A | Human and veterianary medicine; veneral diseases respiratory diseases, bovine mastitis | BEECHAM GROUP PLC (GB) | 1991-08-20 | — | — | US | disclosed |
| US-4812470-A | Antibacterial monic acid derivatives | BEECHAM GROUP P.L.C. (GB) | 1989-03-14 | — | — | US | disclosed |
| EP-0087953-B1 | ANTIBACTERIAL 1-NORMON-2-YL-HETEROCYCLIC COMPOUNDS | BEECHAM GROUP PLC (GB) | 1988-04-27 | — | — | EP | disclosed |
| EP-0087953-A2 | Antibacterial 1-normon-2-yl-heterocyclic compounds | BEECHAM GROUP PLC (GB) | 1983-09-07 | — | — | EP | disclosed |
| EP-0034754-A1 | 2-((3-amino-2-hydroxy-propoxy)-styryl) isoxazoles, process for their preparation and pharmaceutical compositions containing them | BASF Aktiengesellschaft (DE) | 1981-09-02 | — | — | EP | disclosed |