Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864112 | 0.96 | SLC6A3 (0.61) | SLC6A3SLC6A4SLC6A2KCNH2CHRM2 | |
| SCHEMBL9864143 | 0.88 | SLC6A3 (0.64) | SLC6A3SLC6A4SLC6A2KCNH2CHRM2 | |
| SCHEMBL6392408 | 0.85 | SLC6A3 (0.64) | SLC6A3SLC6A4SLC6A2KCNH2CHRM2 | |
| SCHEMBL31107083 | 0.85 | SLC6A3 (0.72) | SLC6A3SLC6A4SLC6A2KCNH2CHRM2 | |
| SCHEMBL31107082 | 0.85 | SLC6A3 (0.72) | SLC6A3SLC6A4SLC6A2KCNH2CHRM2 | |
| Hydrochloric Acid SCHEMBL31107081 | 0.84 | SLC6A3 (0.70) | SLC6A3SLC6A4SLC6A2KCNH2CHRM2 | |
| SCHEMBL9863826 | 0.83 | SLC6A3 (0.59) | SLC6A3SLC6A4SLC6A2KCNH2CHRM2 | |
| SCHEMBL10543400 | 0.83 | SLC6A3 (0.73) | SLC6A3SLC6A4SLC6A2KCNH2CHRM2 | |
| SCHEMBL9864378 | 0.83 | SLC6A3 (0.62) | SLC6A3SLC6A4SLC6A2KCNH2CHRM2 | |
| SCHEMBL9864157 | 0.83 | SLC6A3 (0.62) | SLC6A3SLC6A4SLC6A2KCNH2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |