Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | RORC | P51449 | 4/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864713 | 0.89 | SLC6A3 (0.42) | TP53CYP3A4ALOX15TSHRSLC6A3 | |
| SCHEMBL9864551 | 0.88 | SLC6A4 (0.51) | TP53CYP3A4ALOX15TSHRSLC6A3 | |
| SCHEMBL9864669 | 0.88 | TP53 (0.36) | TP53CYP3A4ALOX15TSHRSLC6A3 | |
| SCHEMBL9864286 | 0.84 | SLC6A3 (0.43) | TP53CYP3A4ALOX15TSHRSLC6A3 | |
| SCHEMBL9863736 | 0.82 | TP53 (0.43) | TP53CYP3A4ALOX15TSHRSLC6A3 | |
| SCHEMBL9864270 | 0.79 | TP53 (0.41) | TP53CYP3A4ALOX15TSHRSLC6A3 | |
| SCHEMBL10900716 | 0.78 | SLC6A3 (0.41) | TP53CYP3A4ALOX15TSHRSLC6A3 | |
| SCHEMBL9864477 | 0.77 | SLC6A3 (0.44) | TP53CYP3A4ALOX15TSHRSLC6A3 | |
| SCHEMBL9864088 | 0.77 | SLC6A4 (0.52) | TP53CYP3A4ALOX15TSHRSLC6A3 | |
| SCHEMBL9864232 | 0.77 | SLC6A4 (0.58) | TP53CYP3A4ALOX15TSHRSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |