Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865905 | 0.98 | NPC1 (0.46) | NPC1RAB9AHPGDSMN1; SMN2SCN5A | |
| SCHEMBL9865894 | 0.94 | SCN5A (0.45) | NPC1RAB9AHPGDSMN1; SMN2SCN5A | |
| SCHEMBL9865887 | 0.94 | SCN5A (0.45) | NPC1RAB9AHPGDSMN1; SMN2SCN5A | |
| SCHEMBL9865114 | 0.92 | SCN5A (0.44) | NPC1RAB9AHPGDSMN1; SMN2SCN5A | |
| SCHEMBL9865122 | 0.92 | SCN5A (0.44) | NPC1RAB9AHPGDSMN1; SMN2SCN5A | |
| SCHEMBL11080978 | 0.89 | HRH2 (0.47) | NPC1RAB9ASCN5ASCN2AHRH2 | |
| SCHEMBL9865196 | 0.88 | HRH2 (0.41) | SMN1; SMN2SCN5ASCN2AHRH2 | |
| SCHEMBL11080965 | 0.87 | HRH2 (0.43) | NPC1RAB9ASCN5ASCN2APOLB | |
| SCHEMBL11080973 | 0.87 | HRH2 (0.43) | NPC1RAB9ASCN5ASCN2APOLB | |
| SCHEMBL9866817 | 0.86 | HRH2 (0.52) | NPC1RAB9ASCN5ASCN2AHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |