Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865178 | 0.93 | HRH2 (0.41) | HRH2SMN1; SMN2SCN5ASCN2AACHE | |
| SCHEMBL9865187 | 0.93 | HRH2 (0.41) | HRH2SMN1; SMN2SCN5ASCN2AACHE | |
| SCHEMBL9865129 | 0.88 | NPC1 (0.48) | HRH2SMN1; SMN2SCN5ASCN2A | |
| SCHEMBL9866822 | 0.88 | HRH2 (0.52) | HRH2SCN5ASCN2AHRH4ALDH1A1 | |
| SCHEMBL9867162 | 0.88 | HRH2 (0.52) | HRH2SCN5ASCN2AHRH4ALDH1A1 | |
| SCHEMBL9866817 | 0.88 | HRH2 (0.52) | HRH2SCN5ASCN2AHRH4ALDH1A1 | |
| SCHEMBL9865348 | 0.87 | HRH2 (0.53) | HRH2SCN5ASCN2AHRH4 | |
| SCHEMBL11080978 | 0.86 | HRH2 (0.47) | HRH2SCN5ASCN2AHRH4 | |
| SCHEMBL9865905 | 0.86 | NPC1 (0.46) | HRH2SMN1; SMN2SCN5ASCN2A | |
| SCHEMBL9865344 | 0.85 | HRH2 (0.49) | HRH2SCN5ASCN2AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |