Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL28843868 | 0.98 | KDM4E (0.44) | KDM4EPOLBALDH1A1CYP4A11CYP4F2 | |
| SCHEMBL16056735 | 0.93 | CYP2A6 (0.42) | KDM4EPOLBALDH1A1CYP4A11CYP4F2 | |
| SCHEMBL3365956 | 0.87 | ALDH1A1 (0.44) | KDM4EPOLBALDH1A1CYP1A2CYP2A6 | |
| SCHEMBL9580544 | 0.87 | TRPA1 (0.46) | KDM4EPOLBALDH1A1CYP4A11CYP4F2 | |
| SCHEMBL28117674 | 0.85 | KDM4E (0.40) | KDM4EPOLBALDH1A1CYP4A11CYP4F2 | |
| SCHEMBL533943 | 0.85 | ALDH1A1 (0.48) | KDM4EPOLBALDH1A1CYP4A11CYP4F2 | |
| SCHEMBL20749154 | 0.85 | TAAR1 (0.42) | KDM4EPOLBCYP4A11CYP4F2TAAR1 | |
| SCHEMBL10581584 | 0.85 | CD44 (0.45) | KDM4EPOLBALDH1A1CYP4A11CYP4F2 | |
| SCHEMBL8096178 | 0.84 | CYP2A6 (0.45) | ALDH1A1CYP1A2CYP2A6TRPA1ATM | |
| SCHEMBL8095408 | 0.84 | CYP2A6 (0.45) | ALDH1A1CYP1A2CYP2A6TRPA1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107496899-A | Aromatic-cationic peptide and use their method | 梅约医学教育与研究基金会 | 2017-12-22 | — | — | CN | disclosed |
| CN-107219358-A | Aromatic-cationic peptides and application thereof | 康奈尔大学 | 2017-09-29 | — | — | CN | disclosed |
| CN-106913860-A | Aromatic-cationic peptide and use their method | 梅约医学教育与研究基金会 | 2017-07-04 | — | — | CN | disclosed |
| CN-104107417-B | Methods For Preventing Or Treating Insulin Resistance | 康奈尔大学 | 2017-04-12 | — | — | CN | disclosed |
| CN-104225574-B | METHODS FOR PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION | 科内尔研究基金会 | 2017-01-11 | — | — | CN | disclosed |
| EP-2797896-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN, INC. (US) | 2014-11-05 | — | — | EP | disclosed |
| US-20130172342-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-20130172342-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-20130172342-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| WO-2013101926-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN, INC. (US) | 2013-07-04 | — | — | WO | disclosed |
| WO-2013101926-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN, INC. (US) | 2013-07-04 | — | — | WO | disclosed |
| US-5011938-A | Antimicrobials | ELI LILLY AND COMPANY (US) | 1991-04-30 | — | — | US | disclosed |
| US-4940718-A | BACTERICIDES | ELI LILLY AND COMPANY (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0202046-A1 | 7-Substituted bicyclic pyrazolidinones | ELI LILLY AND COMPANY (US) | 1986-11-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172342-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | SCN1B, SCN2B, SCN1A | KDM4E 2165/4885POLB 3501/4885ALDH1A1 942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.