Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.32 |
| ▸ | POR | P16435 | 1/20 | 0.32 |
| ▸ | PTPRC | P08575 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67627 | 0.63 | ALDH1A1 (0.51) | — | |
| SCHEMBL9303172 | 0.60 | KDM4E (0.32) | — | |
| SCHEMBL10570772 | 0.60 | NQO1 (0.32) | NQO1PORPTPRC | |
| SCHEMBL14430353 | 0.58 | HSD17B10 (0.36) | NQO1POR | |
| SCHEMBL16098860 | 0.58 | CA1 (0.43) | PTPRC | |
| SCHEMBL9864191 | 0.56 | VHL (0.41) | PTPRC | |
| SCHEMBL9623158 | 0.55 | TDP1 (0.51) | — | |
| SCHEMBL23624638 | 0.55 | NPC1 (0.50) | PTPRC | |
| SCHEMBL353445 | 0.53 | PTPRC (0.31) | PTPRC | |
| SCHEMBL699539 | 0.49 | PTPRC (0.50) | NQO1PORPTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045561-A | Substituted furan sulfonamides as antiglaucoma agents | MERCK & CO., INC. (US) | 1991-09-03 | — | — | US | disclosed |
| US-4863922-A | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use | MERCK & CO., INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0296879-A1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-28 | — | — | EP | disclosed |