Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 14/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215591 | 1.00 | IRAK4 (0.37) | IRAK4GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL15727499 | 0.91 | IRAK4 (0.39) | IRAK4GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL21180014 | 0.91 | IRAK4 (0.39) | IRAK4GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL4378121 | 0.90 | IRAK4 (0.35) | IRAK4ALOX5 | |
| SCHEMBL11920249 | 0.79 | IRAK4 (0.39) | IRAK4GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL9851967 | 0.76 | IRAK4 (0.38) | IRAK4IRAK1 | |
| SCHEMBL12409742 | 0.76 | — | — | |
| SCHEMBL12459955 | 0.76 | — | — | |
| SCHEMBL9865753 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL27036387 | 0.74 | IRAK4 (0.39) | IRAK4PDK2IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066651-A | Sulfonyl group attached to nitrogen, Alzheimer*s disease, antihypoxic, antiischemic, memory lapses | ADIR ET COMPAGNIE (FR) | 1991-11-19 | — | — | US | disclosed |
| US-4113873-A | 8-AZAPROSTANOIC ACID DERIVATIVES | TANABE SEIYAKU CO. LTD. (JP) | 1978-09-12 | — | — | US | disclosed |