Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 6/20 | 0.37 |
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865180 | 0.88 | LMNA (0.45) | LMNACCR5SIGMAR1HRH1HTR2A | |
| SCHEMBL28343866 | 0.83 | NR1I2 (0.49) | LMNACCR5NR1I2SIGMAR1HRH1 | |
| SCHEMBL598619 | 0.83 | NR1I2 (0.49) | LMNACCR5NR1I2SIGMAR1HRH1 | |
| SCHEMBL169508 | 0.82 | LMNA (0.56) | LMNACCR5HRH1HTR2ATAAR1 | |
| SCHEMBL6685367 | 0.82 | NR1I2 (0.56) | LMNACCR5NR1I2SIGMAR1HTR2A | |
| Ammonia Solution, Strong SCHEMBL1640901 | 0.80 | LMNA (0.54) | LMNACCR5HRH1HTR2ATAAR1 | |
| SCHEMBL3097530 | 0.80 | NR1I2 (0.58) | LMNANR1I2SIGMAR1HTR2AKDM4E | |
| SCHEMBL3385362 | 0.80 | LMNA (0.42) | LMNACCR5NR1I2SIGMAR1HRH1 | |
| SCHEMBL7719078 | 0.80 | NR1I2 (0.58) | LMNANR1I2SIGMAR1HTR2AKDM4E | |
| SCHEMBL22426629 | 0.80 | CCR5 (0.44) | LMNACCR5NR1I2SIGMAR1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011938-A | Antimicrobials | ELI LILLY AND COMPANY (US) | 1991-04-30 | — | — | US | disclosed |
| US-4940718-A | BACTERICIDES | ELI LILLY AND COMPANY (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0202046-A1 | 7-Substituted bicyclic pyrazolidinones | ELI LILLY AND COMPANY (US) | 1986-11-20 | — | — | EP | disclosed |