Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9868517 | 0.85 | KMT2A (0.42) | SMN1; SMN2POLBLMNAKMT2AALDH1A1 | |
| SCHEMBL9866369 | 0.85 | HRH2 (0.46) | SMN1; SMN2LMNA | |
| SCHEMBL9865116 | 0.84 | HRH2 (0.31) | SMN1; SMN2LMNAKMT2ACYP1A2CYP3A4 | |
| SCHEMBL9866034 | 0.80 | ALDH1A1 (0.45) | SMN1; SMN2POLBLMNAKMT2AALDH1A1 | |
| SCHEMBL9866446 | 0.79 | SMN1; SMN2 (0.35) | SMN1; SMN2POLBLMNAKMT2AALDH1A1 | |
| Impromidine SCHEMBL407158 | 0.78 | SLC47A1 (0.47) | SMN1; SMN2LMNAKMT2ACYP1A2CYP3A4 | |
| Impromidine SCHEMBL636059 | 0.77 | HRH2 (0.47) | SMN1; SMN2LMNAKMT2ACYP1A2CYP3A4 | |
| Impromidine SCHEMBL7175042 | 0.77 | HRH2 (0.47) | SMN1; SMN2LMNAKMT2ACYP1A2CYP3A4 | |
| Impromidine SCHEMBL7177531 | 0.77 | HRH2 (0.47) | SMN1; SMN2LMNAKMT2ACYP1A2CYP3A4 | |
| SCHEMBL7175108 | 0.76 | SLC47A1 (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |