Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9868517 | 0.89 | KMT2A (0.42) | ALDH1A1LMNAHPGDPOLBSMN1; SMN2 | |
| SCHEMBL9865256 | 0.88 | ALDH1A1 (0.45) | ALDH1A1LMNAPOLBSMN1; SMN2KMT2A | |
| SCHEMBL9876539 | 0.88 | CYP1A2 (0.38) | ALDH1A1LMNAHPGDSMN1; SMN2HTT | |
| SCHEMBL9877140 | 0.85 | ALDH1A1 (0.40) | ALDH1A1LMNAHPGDPOLBSMN1; SMN2 | |
| SCHEMBL9867267 | 0.84 | LMNA (0.35) | ALDH1A1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL9867195 | 0.83 | HPGD (0.39) | ALDH1A1LMNAHPGDPOLBKMT2A | |
| SCHEMBL9867335 | 0.83 | EPHX2 (0.35) | ALDH1A1LMNAHPGDSMN1; SMN2 | |
| Impromidine SCHEMBL7171545 | 0.83 | HRH2 (0.32) | LMNASMN1; SMN2KMT2AMEN1 | |
| Impromidine SCHEMBL407158 | 0.83 | SLC47A1 (0.47) | LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9865647 | 0.82 | GAA (0.45) | ALDH1A1LMNAHPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |