Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.77 |
| ▸ | NPC1 | O15118 | 5/20 | 0.77 |
| ▸ | RAB9A | P51151 | 5/20 | 0.77 |
| ▸ | MAPT | P10636 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.57 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.57 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28051161 | 0.98 | SMN1; SMN2 (0.74) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL9867091 | 0.98 | SMN1; SMN2 (0.73) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL9867405 | 0.93 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL4427177 | 0.88 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL23736058 | 0.88 | NPC1 (1.00) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL2377367 | 0.88 | NPC1 (1.00) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL8165938 | 0.88 | NPC1 (1.00) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL3076504 | 0.88 | NPC1 (1.00) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL6850969 | 0.85 | SMN1; SMN2 (0.94) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL3076671 | 0.79 | NPC1 (0.73) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104936961-B | The preparation method of (1S, 4S, 5S)-4-bromo-6-oxabicyclo [3.2.1] octyl-7-ketone | 第三共株式会社 | 2016-10-26 | — | — | CN | claimed |
| CN-103214414-B | The diamine derivative of opticity and manufacture method thereof | SANKYO CO. (JP) | 2016-02-17 | — | — | CN | disclosed |
| CN-103140466-B | Compound oxygen radical of nitrogen is adopted to prepare the method for compound through the reaction of new sandmeyer type as catalysts | DAIICHI SANKYO Co.,Ltd. (JP) | 2016-02-17 | — | — | CN | disclosed |
| CN-105008325-A | Processes for preparing optically active diamine derivatives | DAIICHI SANKYO CO LTD | 2015-10-28 | — | — | CN | disclosed |
| CN-104936961-A | Method for producing (1S,4S,5S)-4-bromo-6- oxabicyclo[3.2.1]octane-7-one | DAIICHI SANKYO CO LTD | 2015-09-23 | — | — | CN | disclosed |
| CN-103080078-B | Process for producing optically active diamine derivative salt | DAIICHI SANKYO CO LTD | 2015-02-11 | — | — | CN | disclosed |
| CN-104324015-A | PHARMACEUTICAL COMPOSITION | DAIICHI SANKYO CO LTD | 2015-02-04 | — | — | CN | disclosed |
| US-5051517-A | Reacting a chloroformidine hydrochloride with an oxamohydrazide, forming bonds between carbon and nitrogen and cyclization | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-24 | — | — | US | disclosed |
| EP-0126326-B1 | PROCESS FOR PREPARING 1,2,4-TRIAZOLE-3-CARBOXAMIDES | UBE INDUSTRIES, LTD. (JP) | 1987-08-05 | — | — | EP | disclosed |
| US-4578479-A | Process for preparing 1,2,4-triazole-3-carboxamides | UBE INDUSTRIES, LTD. (JP) | 1986-03-25 | — | — | US | disclosed |
| EP-0126326-A1 | Process for preparing 1,2,4-triazole-3-carboxamides | UBE INDUSTRIES, LTD. (JP) | 1984-11-28 | — | — | EP | disclosed |