Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866596 | 0.84 | ACHE (0.49) | ACHECYP3A4CYP2D6MAPTHRH2 | |
| Hydrochloric Acid SCHEMBL11041744 | 0.80 | ACHE (0.33) | ACHEMAPT | |
| SCHEMBL9865116 | 0.79 | HRH2 (0.31) | CYP3A4CYP2D6HRH2 | |
| Hydrochloric Acid SCHEMBL11081091 | 0.79 | ACHE (0.52) | ACHEMAPTHRH2 | |
| SCHEMBL9868582 | 0.77 | ACHE (0.42) | ACHECYP3A4CYP2D6MAPTHRH2 | |
| SCHEMBL10873978 | 0.77 | ACHE (0.39) | ACHEMAPTHRH2 | |
| SCHEMBL10969829 | 0.76 | ACHE (0.56) | ACHECYP3A4CYP2D6MAPTHRH2 | |
| SCHEMBL9866415 | 0.76 | CYP3A4 (0.34) | CYP3A4CYP2D6MAPTHRH2 | |
| SCHEMBL10860045 | 0.76 | LMNA (0.30) | CYP3A4CYP2D6HRH2 | |
| SCHEMBL11181168 | 0.75 | ACHE (0.66) | ACHECYP3A4CYP2D6MAPTHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |