Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 12/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864843 | 0.84 | PDE10A (0.52) | PDE10AALOX5HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL9018918 | 0.79 | PDE10A (0.57) | PDE10AALOX5HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL9866191 | 0.79 | CYSLTR2 (0.54) | PDE10AALOX5HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL9866102 | 0.78 | CYSLTR2 (0.52) | PDE10AALOX5HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL9866264 | 0.78 | ALOX5 (0.49) | PDE10AALOX5HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL9866614 | 0.75 | ALOX5 (0.51) | PDE10AALOX5HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL8965014 | 0.72 | CYSLTR1 (0.59) | ALOX5HDAC6CYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL9137854 | 0.72 | GPBAR1 (0.66) | PDE10AALOX5HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL9474669 | 0.72 | ALOX5 (0.64) | ALOX5HDAC6CYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL9135133 | 0.72 | GPBAR1 (0.66) | PDE10AALOX5HDAC6CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045547-A | Leukotriene-inhibiting substituted (quinolin-2-yl-methoxy)phenyl-N,N'-sulphonylureas and use thereas | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-03 | — | — | US | claimed |
| US-5045547-A | Leukotriene-inhibiting substituted (quinolin-2-yl-methoxy)phenyl-N,N'-sulphonylureas and use thereas | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-03 | — | — | US | disclosed |