Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866781 | 1.00 | SCN5A (0.46) | SCN5ASCN2ALMNASMN1; SMN2MCHR1 | |
| SCHEMBL9866791 | 0.77 | LMNA (0.45) | LMNASMN1; SMN2HTTATMMAPT | |
| SCHEMBL9865046 | 0.72 | SCN5A (0.59) | SCN5ASCN2ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL9865051 | 0.72 | SCN5A (0.59) | SCN5ASCN2ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL9866134 | 0.70 | SCN5A (0.37) | SCN5ASCN2ALMNASMN1; SMN2MCHR1 | |
| SCHEMBL9866141 | 0.70 | SCN5A (0.37) | SCN5ASCN2ALMNASMN1; SMN2MCHR1 | |
| SCHEMBL9866790 | 0.70 | SCN5A (0.33) | SCN5ASCN2A | |
| SCHEMBL4627550 | 0.69 | SCN2A (0.84) | SCN5ASCN2ALMNASMN1; SMN2 | |
| SCHEMBL9264842 | 0.68 | CYP2C19 (0.67) | LMNASMN1; SMN2HTTATMNR1H4 | |
| SCHEMBL1128514 | 0.67 | HTT (0.53) | LMNASMN1; SMN2HTTATMFTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |