Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 3/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867640 | 0.95 | SCN5A (0.45) | SCN5ASCN2ASMN1; SMN2LMNAHRH2 | |
| SCHEMBL9867644 | 0.95 | SCN5A (0.45) | SCN5ASCN2ASMN1; SMN2LMNAHRH2 | |
| SCHEMBL9867011 | 0.93 | LMNA (0.43) | SCN5ASCN2ASMN1; SMN2LMNAHRH2 | |
| SCHEMBL7433578 | 0.91 | EPHX2 (0.43) | SCN5ASCN2ASMN1; SMN2LMNAHRH2 | |
| SCHEMBL9865901 | 0.91 | HPGD (0.40) | SCN5ASCN2ASMN1; SMN2LMNAHRH2 | |
| SCHEMBL9865896 | 0.91 | HPGD (0.40) | SCN5ASCN2ASMN1; SMN2LMNAHRH2 | |
| SCHEMBL9866000 | 0.91 | SCN5A (0.50) | SCN5ASCN2ASMN1; SMN2LMNAHRH2 | |
| SCHEMBL9866007 | 0.91 | SCN5A (0.50) | SCN5ASCN2ASMN1; SMN2LMNAHRH2 | |
| SCHEMBL9866315 | 0.89 | ALDH1A1 (0.42) | SCN5ASCN2ASMN1; SMN2LMNACYP1A2 | |
| SCHEMBL9866309 | 0.89 | ALDH1A1 (0.42) | SCN5ASCN2ASMN1; SMN2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |