Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.36 |
| ▸ | HRH1 | P35367 | 12/20 | 0.35 |
| ▸ | HRH2 | P25021 | 2/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364955 | 0.95 | S1PR1 (0.36) | HRH3HRH4HRH1HRH2S1PR1 | |
| SCHEMBL7426895 | 0.81 | S1PR1 (0.36) | S1PR1S1PR3 | |
| SCHEMBL10377543 | 0.81 | HTT (0.38) | HRH3HRH4HRH1HRH2 | |
| SCHEMBL10852155 | 0.81 | HRH3 (0.37) | HRH3HRH4HRH1HRH2CXCR4 | |
| SCHEMBL16809676 | 0.80 | S1PR1 (0.39) | HRH4HRH1S1PR1S1PR3 | |
| SCHEMBL10853546 | 0.79 | HRH3 (0.36) | HRH3HRH4HRH1HRH2CXCR4 | |
| SCHEMBL10852507 | 0.79 | HRH3 (0.36) | HRH3HRH4HRH1HRH2CXCR4 | |
| SCHEMBL10851407 | 0.79 | AGBL2 (0.50) | HRH3HRH4HRH1HRH2CXCR4 | |
| SCHEMBL10377450 | 0.79 | HRH2 (0.39) | HRH3HRH4HRH2S1PR1S1PR3 | |
| SCHEMBL18489099 | 0.78 | S1PR1 (0.35) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4584381-A | HISTAMINE H1-ANTAGONIST | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-04-22 | — | — | US | claimed |
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0244201-B1 | 3-HYDROXYPYRIDINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-09-26 | — | — | EP | disclosed |
| EP-0112142-B1 | PYRIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-06-20 | — | — | EP | disclosed |
| US-4863936-A | 3,5-Substituted-2-pyridyl-alkylaminocyclobutenediones having histamine h1 -antagonist activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-09-05 | — | — | US | disclosed |
| US-4863933-A | HISTAMINE H1 ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-09-05 | — | — | US | disclosed |
| US-4764519-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-08-16 | — | — | US | disclosed |
| US-4743692-A | N-(pyridinylalkyl)-thieno-or benzo-isothiazol-3-amine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-05-10 | — | — | US | disclosed |
| EP-0093490-B1 | PROCESS FOR PREPARING 3,5-DISUBSTITUTED 2-PYRIDYLALKYL AMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-04-27 | — | — | EP | disclosed |
| EP-0244201-A2 | 3-Hydroxypyridines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-11-04 | — | — | EP | disclosed |
| US-4537891-A | 2-(3,5-Substituted-2-pyridylalkylamino)-5-benzyl-4-pyrimidones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-08-27 | — | — | US | disclosed |
| US-4537890-A | 2-(3,5-Substituted-2-pyridylalkylamino)-5-oxopyridylmethyl-4-pyrimidones useful as histamine H1 -antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-08-27 | — | — | US | disclosed |
| US-4532252-A | 3,5-Substituted-2-pyridylalkylamino compounds having histamine H1 -antagonist activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-07-30 | — | — | US | disclosed |
| US-4515952-A | Synthesis of 2-pyridylalkylamines substituted on the pyridyl ring by bromine | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-05-07 | — | — | US | disclosed |
| US-4486434-A | PYRIDYLALKYLAMINO PYRIDYLMETHYL PYRIMIDONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-12-04 | — | — | US | disclosed |
| EP-0115132-A1 | Pyrimidone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-08-08 | — | — | EP | disclosed |
| EP-0112142-A2 | Pyridine derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-06-27 | — | — | EP | disclosed |
| EP-0107914-A1 | Aminopyrimidinone derivatives useful as histamine H1-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-05-09 | — | — | EP | disclosed |
| EP-0093490-A2 | Process for preparing 3,5-disubstituted 2-pyridylalkyl amines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-11-09 | — | — | EP | disclosed |
| EP-0068833-A2 | Pyrimidinone derivatives and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-01-05 | — | — | EP | disclosed |