Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430667 | 0.89 | S1PR1 (0.37) | S1PR1S1PR3SMN1; SMN2HTTKMT2A | |
| SCHEMBL10364955 | 0.82 | S1PR1 (0.36) | S1PR1S1PR3SMN1; SMN2HTTKMT2A | |
| SCHEMBL7751886 | 0.81 | S1PR1 (0.39) | S1PR1S1PR3SMN1; SMN2HTTKMT2A | |
| SCHEMBL9867322 | 0.81 | HRH3 (0.36) | S1PR1S1PR3 | |
| SCHEMBL18489099 | 0.79 | S1PR1 (0.35) | S1PR1S1PR3SMN1; SMN2HTTKMT2A | |
| SCHEMBL10377450 | 0.77 | HRH2 (0.39) | S1PR1S1PR3KMT2A | |
| SCHEMBL27374042 | 0.75 | S1PR1 (0.33) | S1PR1S1PR3SMN1; SMN2HTTKMT2A | |
| SCHEMBL29338673 | 0.75 | S1PR1 (0.37) | S1PR1S1PR3SMN1; SMN2HTTKMT2A | |
| SCHEMBL15080876 | 0.75 | S1PR1 (0.37) | S1PR1S1PR3SMN1; SMN2HTTKMT2A | |
| SCHEMBL16809676 | 0.73 | S1PR1 (0.39) | S1PR1S1PR3SMN1; SMN2HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0448765-B1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1994-08-17 | — | — | EP | claimed |
| WO-1992022295-A1 | USE OF GUANIDINE DERIVATIVES IN THE PREPARATION OF A DRUG FOR THE TREATMENT OF SEPSIS AND SEPSIS-LIKE CONDITIONS AND SEPTIC SHOCK | NEUGEBAUER EDMUND (DE) | 1992-12-23 | — | — | WO | claimed |
| EP-0448765-A1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1991-10-02 | — | — | EP | claimed |
| EP-0448765-B1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1994-08-17 | — | — | EP | disclosed |
| WO-1992022295-A1 | USE OF GUANIDINE DERIVATIVES IN THE PREPARATION OF A DRUG FOR THE TREATMENT OF SEPSIS AND SEPSIS-LIKE CONDITIONS AND SEPTIC SHOCK | NEUGEBAUER EDMUND (DE) | 1992-12-23 | — | — | WO | disclosed |
| EP-0448765-A1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1991-10-02 | — | — | EP | disclosed |