Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | POLA1 | P09884 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442457 | 0.84 | TSHR (0.47) | TSHRKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL9865284 | 0.83 | DNM1 (0.46) | TSHRKMT2AALDH1A1KDM5AL3MBTL1 | |
| SCHEMBL18556504 | 0.79 | TSHR (0.58) | TSHRKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL18499076 | 0.79 | KMT2A (0.65) | TSHRKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL711981 | 0.79 | TSHR (0.58) | TSHRKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL15684536 | 0.77 | LMNA (0.35) | LMNAALDH1A1KDM5ADNM1 | |
| SCHEMBL17451524 | 0.77 | TSHR (0.61) | TSHRKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL10084980 | 0.77 | TSHR (0.61) | TSHRKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL3503548 | 0.76 | TSHR (0.82) | TSHRKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL494114 | 0.76 | TSHR (0.82) | TSHRKMT2AMEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994612-A | Intermediates for dihydropyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-02-19 | — | — | US | disclosed |
| US-4847273-A | CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1989-07-11 | — | — | US | disclosed |