Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.47 |
| ▸ | GLRB | P48167 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ESRRA | P11474 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4122613 | 0.84 | GLRA3 (0.62) | GLRA3GLRBCA2ESRRAALDH1A1 | |
| SCHEMBL3630959 | 0.82 | THRB (0.47) | PRKCITHRBGLRA3GLRBCA2 | |
| SCHEMBL4122067 | 0.79 | CA2 (0.55) | GLRA3GLRBCA2ALDH1A1ALOX15 | |
| SCHEMBL1878648 | 0.78 | THRB (0.61) | PRKCITHRBCA2ALDH1A1HSD17B10 | |
| SCHEMBL6451162 | 0.75 | THRB (0.70) | PRKCITHRBCA2ALDH1A1ALOX15 | |
| SCHEMBL3185583 | 0.73 | PRKCI (0.76) | PRKCITHRBCA9GABRA1GABRB2 | |
| SCHEMBL3169896 | 0.73 | CA2 (0.56) | GLRA3GLRBCA2ALDH1A1ALOX15 | |
| SCHEMBL29488108 | 0.73 | CA2 (0.56) | GLRA3GLRBCA2ALDH1A1ALOX15 | |
| SCHEMBL9312650 | 0.72 | THRB (0.54) | PRKCITHRBALDH1A1ALOX15CYP2C9 | |
| SCHEMBL3280277 | 0.72 | THRB (0.54) | PRKCITHRBCA2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006549-A | Antiinflammatory agents | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0399773-A1 | Novel 7-aroyl-4-hydroxy-3-methyl benzolfurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | disclosed |
| EP-0104018-A2 | Benzopyran, benzothiapyran and quinoline compounds and pharmaceutical compositions containing them | FISONS plc (GB) | 1984-03-28 | — | — | EP | disclosed |